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    Tmie transmembrane inner ear [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501061, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tmieprovided by RGD
    Official Full Name
    transmembrane inner earprovided by RGD
    Primary source
    RGD:1562523
    See related
    Ensembl:ENSRNOG00000027799 AllianceGenome:RGD:1562523
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562523
    Summary
    Predicted to be involved in inner ear morphogenesis and sensory perception of sound. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 6 and sensorineural hearing loss. Orthologous to human TMIE (transmembrane inner ear). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 21.6), Brain (RPKM 11.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmie in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119728123..119743219, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110849713..110864803, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119142116..119157071, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protease, serine, 46 Neighboring gene serine protease 50 Neighboring gene uncharacterized LOC120094265 Neighboring gene ALS2 C-terminal like Neighboring gene family with sequence similarity 240 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal expression of tmie in the inner ear of rats during postnatal development. Shin MJ, et al. Comp Med, 2010 Aug. PMID 20819378, Free PMC Article
    2. Expression and localization of Tmie in adult rat cochlea. Su MC, et al. Histochem Cell Biol, 2008 Jul. PMID 18327602
    3. Mutations in a novel gene, TMIE, are associated with hearing loss linked to the DFNB6 locus. Naz S, et al. Am J Hum Genet, 2002 Sep. PMID 12145746, Free PMC Article
    4. Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. Mitchem KL, et al. Hum Mol Genet, 2002 Aug 1. PMID 12140191
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in inner ear morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane inner ear expressed protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109299.1 → NP_001102769.1  transmembrane inner ear expressed protein

      See identical proteins and their annotated locations for NP_001102769.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A6I3H9, D4AE26
      Related
      ENSRNOP00000029990.2, ENSRNOT00000028963.3
      Conserved Domains (1) summary
      pfam16038
      Location:47 → 132
      TMIE; TMIE protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119728123..119743219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266010.1 → XP_063122080.1  transmembrane inner ear expressed protein isoform X3

    2. XM_063266009.1 → XP_063122079.1  transmembrane inner ear expressed protein isoform X2

      UniProtKB/TrEMBL
      A6I3H9, D4AE26

    3. XM_006243996.5 → XP_006244058.1  transmembrane inner ear expressed protein isoform X2

      See identical proteins and their annotated locations for XP_006244058.1

      UniProtKB/TrEMBL
      A6I3H9, D4AE26
      Conserved Domains (1) summary
      pfam16038
      Location:47 → 132
      TMIE; TMIE protein

    4. XM_039081994.2 → XP_038937922.1  transmembrane inner ear expressed protein isoform X1

      Conserved Domains (1) summary
      pfam16038
      Location:88 → 164
      TMIE; TMIE protein

    5. XM_006243995.5 → XP_006244057.1  transmembrane inner ear expressed protein isoform X1

      See identical proteins and their annotated locations for XP_006244057.1

      Conserved Domains (1) summary
      pfam16038
      Location:88 → 164
      TMIE; TMIE protein
    Nucleotide Protein Strain
    Heading Accession and Version

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