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    Cdkn3 cyclin-dependent kinase inhibitor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289993, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cdkn3provided by RGD
    Official Full Name
    cyclin-dependent kinase inhibitor 3provided by RGD
    Primary source
    RGD:1307781
    See related
    Ensembl:ENSRNOG00000009785 AllianceGenome:RGD:1307781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 330.4), Thymus (RPKM 106.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdkn3 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (22502299..22513725)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20022522..20033948)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (23553171..23564538)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S16, pseudogene 2 Neighboring gene uncharacterized LOC134481956 Neighboring gene cornichon family member 1 Neighboring gene glia maturation factor, beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma. Dai W, et al. Mol Med Rep, 2016 Aug. PMID 27314282, Free PMC Article
    2. Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth. Lin WR, et al. Oncol Rep, 2013 Mar. PMID 23292002, Free PMC Article
    3. Cyclin-dependent kinase inhibitor 3 is overexpressed in hepatocellular carcinoma and promotes tumor cell proliferation. Xing C, et al. Biochem Biophys Res Commun, 2012 Mar 30. PMID 22390936
    4. Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. Lee SW, et al. Mol Cell Biol, 2000 Mar. PMID 10669749, Free PMC Article
    5. Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant. Yeh CT, et al. Biochem Biophys Res Commun, 2003 May 30. PMID 12745075

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase inhibitor 3
    Names
    CDK2-associated dual-specificity phosphatase
    kinase-associated phosphatase
    NP_001099498.1
    NP_001387969.1
    XP_006251854.1
    XP_063130163.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106028.1 → NP_001099498.1  cyclin-dependent kinase inhibitor 3 isoform 2

      See identical proteins and their annotated locations for NP_001099498.1

      Status: VALIDATED

      Source sequence(s)
      CH474040
      UniProtKB/TrEMBL
      A6KE22
      Conserved Domains (1) summary
      cl21483
      Location:1 → 139
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001401040.1 → NP_001387969.1  cyclin-dependent kinase inhibitor 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      B2RZ50
      Related
      ENSRNOP00000012985.5, ENSRNOT00000012985.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      22502299..22513725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251792.4 → XP_006251854.1  cyclin-dependent kinase inhibitor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARV6
      Conserved Domains (1) summary
      cl21483
      Location:1 → 167
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_063274093.1 → XP_063130163.1  cyclin-dependent kinase inhibitor 3 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RZ50.1 GenPept UniProtKB/Swiss-Prot:B2RZ50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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