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    Bcl2l13 Bcl2-like 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312682, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Bcl2l13provided by RGD
    Official Full Name
    Bcl2-like 13provided by RGD
    Primary source
    RGD:1306985
    See related
    Ensembl:ENSRNOG00000012394 AllianceGenome:RGD:1306985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in apoptotic process and regulation of apoptotic process. Predicted to be active in mitochondrion. Predicted to be integral component of membrane. Orthologous to human BCL2L13 (BCL2 like 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 190.4), Muscle (RPKM 184.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcl2l13 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155728284..155785058)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154056116..154112890)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153385200..153438096)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 18 Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene BH3 interacting domain death agonist Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene uncharacterized LOC134486634

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13. Jiang D, et al. Biomed Pharmacother, 2019 Sep. PMID 31200256
    2. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. Kataoka T, et al. J Biol Chem, 2001 Jun 1. PMID 11262395
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-874-3p attenuated ischemic injury by negatively regulating BMF and BCL2L13.
      Title: Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bcl-2-like protein 13
    Names
    BCL2-like 13 (apoptosis facilitator)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398849.1 → NP_001385778.1  bcl-2-like protein 13

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZT71
      Related
      ENSRNOP00000016561.6, ENSRNOT00000016561.8
      Conserved Domains (1) summary
      pfam00452
      Location:104 → 200
      Bcl-2; Apoptosis regulator proteins, Bcl-2 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      155728284..155785058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286121.1 → XP_063142191.1  bcl-2-like protein 13 isoform X2

    2. XM_063286122.1 → XP_063142192.1  bcl-2-like protein 13 isoform X3

    3. XM_063286120.1 → XP_063142190.1  bcl-2-like protein 13 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107885.1: Suppressed sequence

      Description
      NM_001107885.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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