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    Eif3m eukaryotic translation initiation factor 3, subunit M [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295975, updated on 4-May-2024

    Summary

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    Official Symbol
    Eif3mprovided by RGD
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Mprovided by RGD
    Primary source
    RGD:1565840
    See related
    Ensembl:ENSRNOG00000012738 AllianceGenome:RGD:1565840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565840
    Summary
    Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Orthologous to human EIF3M (eukaryotic translation initiation factor 3 subunit M). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 851.0), Thymus (RPKM 842.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif3m in Genome Data Viewer
    Location:
    3q33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (111879589..111897193, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (91424754..91442358, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (94990086..95007690, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17, pseudogene 17 Neighboring gene coiled-coil domain containing 73 Neighboring gene uncharacterized LOC134486134 Neighboring gene gamma-aminobutyric acid receptor-associated protein-like 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. Zeng L, et al. J Biol Chem, 2013 Oct 18. PMID 24003236, Free PMC Article
    2. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181
    3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Lee AS, et al. Nature, 2015 Jun 4. PMID 25849773, Free PMC Article
    4. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Damoc E, et al. Mol Cell Proteomics, 2007 Jul. PMID 17322308
    5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Zhou M, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 18599441, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit M
    NP_001161995.1
    XP_038960460.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168523.1 → NP_001161995.1  eukaryotic translation initiation factor 3 subunit M isoform 1

      See identical proteins and their annotated locations for NP_001161995.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNV6, D3ZAZ0
      Related
      ENSRNOP00000017409.6, ENSRNOT00000017409.8
      Conserved Domains (1) summary
      smart00088
      Location:269 → 357
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    2. NM_001429982.1 → NP_001416911.1  eukaryotic translation initiation factor 3 subunit M isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      111879589..111897193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104532.2 → XP_038960460.1  eukaryotic translation initiation factor 3 subunit M isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR56
      Related
      ENSRNOP00000079525.1
      Conserved Domains (1) summary
      smart00088
      Location:206 → 294
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    Nucleotide Protein Strain
    Heading Accession and Version

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