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    Mrap2 melanocortin 2 receptor accessory protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363112, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mrap2provided by RGD
    Official Full Name
    melanocortin 2 receptor accessory protein 2provided by RGD
    Primary source
    RGD:1309873
    See related
    Ensembl:ENSRNOG00000010545 AllianceGenome:RGD:1309873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309873
    Summary
    Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Predicted to be involved in several processes, including energy homeostasis; negative regulation of protein localization to plasma membrane; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human MRAP2 (melanocortin 2 receptor accessory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 48.3), Thymus (RPKM 26.1) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrap2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (96968239..97024581)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (88088293..88144636)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94801336..94858192)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ripply transcriptional repressor 2 Neighboring gene cytochrome b5 reductase 4 Neighboring gene centrosomal protein 162 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sebag JA, et al. Sci Signal, 2010 Apr 6. PMID 20371771, Free PMC Article
    2. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Asai M, et al. Science, 2013 Jul 19. PMID 23869016, Free PMC Article
    3. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Chan LF, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19329486, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables corticotropin hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables corticotropin hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 1 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 1 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 3 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 3 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 4 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 4 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 5 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 5 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    melanocortin-2 receptor accessory protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108774.1 → NP_001102244.1  melanocortin-2 receptor accessory protein 2

      See identical proteins and their annotated locations for NP_001102244.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A0A0G2K8R5, A6I1X3, D4AE95
      Related
      ENSRNOP00000014006.6, ENSRNOT00000014007.8
      Conserved Domains (1) summary
      pfam15183
      Location:16 → 101
      MRAP; Melanocortin-2 receptor accessory protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      96968239..97024581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243488.5 → XP_006243550.1  melanocortin-2 receptor accessory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243550.1

      UniProtKB/TrEMBL
      A0A0G2K8R5, A6I1X3, D4AE95
      Conserved Domains (1) summary
      pfam15183
      Location:16 → 101
      MRAP; Melanocortin-2 receptor accessory protein family

    2. XM_063265792.1 → XP_063121862.1  melanocortin-2 receptor accessory protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8R5, A6I1X3, D4AE95

    3. XM_006243487.5 → XP_006243549.1  melanocortin-2 receptor accessory protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243549.1

      UniProtKB/TrEMBL
      A0A0G2K8R5, A6I1X3, D4AE95
      Conserved Domains (1) summary
      pfam15183
      Location:16 → 101
      MRAP; Melanocortin-2 receptor accessory protein family

    4. XM_017595743.3 → XP_017451232.1  melanocortin-2 receptor accessory protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8R5, A6I1X3, D4AE95
      Conserved Domains (1) summary
      pfam15183
      Location:16 → 101
      MRAP; Melanocortin-2 receptor accessory protein family

    5. XM_063265794.1 → XP_063121864.1  melanocortin-2 receptor accessory protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8R5, A6I1X3, D4AE95

    6. XM_039081764.2 → XP_038937692.1  melanocortin-2 receptor accessory protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8R5, A6I1X3, D4AE95
      Conserved Domains (1) summary
      pfam15183
      Location:16 → 101
      MRAP; Melanocortin-2 receptor accessory protein family

    7. XM_039081765.2 → XP_038937693.1  melanocortin-2 receptor accessory protein 2 isoform X2

      Conserved Domains (1) summary
      pfam15183
      Location:1 → 40
      MRAP; Melanocortin-2 receptor accessory protein family
    Nucleotide Protein Strain
    Heading Accession and Version

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