Dlst dihydrolipoamide S-succinyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlstprovided by RGD
Official Full Name: dihydrolipoamide S-succinyltransferaseprovided by RGD
Primary source: RGD:1359615
See related: Ensembl:ENSRNOG00000005061 AllianceGenome:RGD:1359615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chaperone binding activity; dihydrolipoyllysine-residue succinyltransferase activity; and heat shock protein binding activity. Involved in 2-oxoglutarate metabolic process and NADH metabolic process. Located in mitochondrion and plasma membrane. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 866.4), Kidney (RPKM 659.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (110489576..110512841)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (104758511..104783296)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (108936534..108961322)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the DLST gene produces two different proteins with quite different functions via alternative splicing.
Title: A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127785 (e-PCR)
- UniSTS:211095

GDB:632554 (e-PCR)
- UniSTS:158461

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables dihydrolipoyllysine-residue succinyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydrolipoyllysine-residue succinyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydrolipoyllysine-residue succinyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dihydrolipoyllysine-residue succinyltransferase activity	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 2-oxoglutarate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine	IEA Inferred from Electronic Annotation more info
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in succinyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in succinyl-CoA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IC Inferred by Curator more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of oxidoreductase complex	IEA Inferred from Electronic Annotation more info
part_of oxoglutarate dehydrogenase complex	IDA Inferred from Direct Assay more info	PubMed
part_of oxoglutarate dehydrogenase complex	IEA Inferred from Electronic Annotation more info
part_of oxoglutarate dehydrogenase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Names: 2-oxoglutarate dehydrogenase complex component E2; E2; E2K; OGDC-E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex

NP_001006982.2

EC 2.3.1.61

XP_006240368.1

EC 2.3.1.61

XP_008762978.1

EC 2.3.1.61

XP_038967973.1

EC 2.3.1.61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006981.2 → NP_001006982.2 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

See identical proteins and their annotated locations for NP_001006982.2

Status: VALIDATED

Source sequence(s)

BC083858, CB807447, CK355938, CK845707

UniProtKB/Swiss-Prot

Q01205, Q5XI35

UniProtKB/TrEMBL

A6JE02, G3V6P2

Related

ENSRNOP00000007298.4, ENSRNOT00000007298.5

Conserved Domains (3) summary

cd06849
Location:72 → 144

lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...

TIGR01347
Location:72 → 454

sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)

pfam00198
Location:239 → 452

2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

110489576..110512841

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240306.3 → XP_006240368.1 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

UniProtKB/TrEMBL

Q8CJG5

Conserved Domains (3) summary

cd06849
Location:97 → 169

lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...

TIGR01347
Location:97 → 479

sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)

pfam00198
Location:264 → 477

2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
XM_008764756.3 → XP_008762978.1 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X3

UniProtKB/TrEMBL

D0VYQ0

Conserved Domains (1) summary

pfam00198
Location:55 → 268

2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
XM_039112045.2 → XP_038967973.1 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X2

UniProtKB/Swiss-Prot

Q01205, Q5XI35

UniProtKB/TrEMBL

Q8CJG5

Conserved Domains (1) summary

TIGR01347
Location:25 → 407

sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)