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    Cdc26 cell division cycle 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366381, updated on 2-May-2024

    Summary

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    Official Symbol
    Cdc26provided by RGD
    Official Full Name
    cell division cycle 26provided by RGD
    Primary source
    RGD:1311342
    See related
    AllianceGenome:RGD:1311342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BWK-2
    Summary
    Predicted to be involved in protein K11-linked ubiquitination and regulation of mitotic cell cycle. Predicted to be part of anaphase-promoting complex. Orthologous to human CDC26 (cell division cycle 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 100.4), Brain (RPKM 87.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc26 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80861658..80875326, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75844852..75859830, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78252168..78267137, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 31 member 2 Neighboring gene FKBP prolyl isomerase family member 15 Neighboring gene solute carrier family 31 member 1 Neighboring gene pre-mRNA splicing tri-snRNP complex factor 4 Neighboring gene ring finger protein 183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. Gmachl M, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922056, Free PMC Article
    2. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit CDC26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013240.2 → NP_001013258.1  anaphase-promoting complex subunit CDC26

      See identical proteins and their annotated locations for NP_001013258.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC086343, FM103539
      UniProtKB/Swiss-Prot
      Q6YDN7
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 64
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    2. NM_001267054.1 → NP_001253983.1  anaphase-promoting complex subunit CDC26

      See identical proteins and their annotated locations for NP_001253983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6YDN7
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 64
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    3. NM_001267055.1 → NP_001253984.1  anaphase-promoting complex subunit CDC26

      See identical proteins and their annotated locations for NP_001253984.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC086343, DY317988, FM103539
      UniProtKB/Swiss-Prot
      Q6YDN7
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 64
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    4. NM_001395703.1 → NP_001382632.1  anaphase-promoting complex subunit CDC26

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6YDN7
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 64
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    5. NM_001395704.1 → NP_001382633.1  anaphase-promoting complex subunit CDC26

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6YDN7
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 64
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      80861658..80875326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288109.1 → XP_063144179.1  anaphase-promoting complex subunit CDC26 isoform X1

      UniProtKB/Swiss-Prot
      Q6YDN7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6YDN7.1 GenPept UniProtKB/Swiss-Prot:Q6YDN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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