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    Fhdc1 FH2 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295161, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fhdc1provided by RGD
    Official Full Name
    FH2 domain containing 1provided by RGD
    Primary source
    RGD:1311955
    See related
    Ensembl:ENSRNOG00000024594 AllianceGenome:RGD:1311955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311955
    Summary
    Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in Golgi ribbon formation; cilium assembly; and stress fiber assembly. Predicted to be located in Golgi apparatus; cilium; and cytoplasmic microtubule. Orthologous to human FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 93.6), Lung (RPKM 49.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fhdc1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (172088987..172127838, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169790917..169829580, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (183450608..183487820, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 2 Neighboring gene uncharacterized LOC102550635 Neighboring gene uncharacterized LOC134485931 Neighboring gene uncharacterized LOC120100858 Neighboring gene ADP-ribosylation factor interacting protein 1 Neighboring gene tigger transposable element derived 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Actin- and microtubule-dependent regulation of Golgi morphology by FHDC1. Copeland SJ, et al. Mol Biol Cell, 2016 Jan 15. PMID 26564798, Free PMC Article
    2. INF1 is a novel microtubule-associated formin. Young KG, et al. Mol Biol Cell, 2008 Dec. PMID 18815276, Free PMC Article
    3. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Copeland SJ, et al. Mol Biol Cell, 2018 Jul 1. PMID 29742020, Free PMC Article
    4. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FH2 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106437.1 → NP_001099907.1  FH2 domain-containing protein 1

      See identical proteins and their annotated locations for NP_001099907.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A6J5W7, D3ZL83
      Related
      ENSRNOP00000060810.2, ENSRNOT00000066477.4
      Conserved Domains (3) summary
      PTZ00449
      Location:559 → 760
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:733 → 1128
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam02181
      Location:93 → 457
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      172088987..172127838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102025.2 → XP_038957953.1  FH2 domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J5W7, D3ZL83
      Conserved Domains (3) summary
      PTZ00449
      Location:559 → 760
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03307
      Location:733 → 1128
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam02181
      Location:93 → 457
      FH2; Formin Homology 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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