U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mrpl15 mitochondrial ribosomal protein L15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297799, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mrpl15provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L15provided by RGD
    Primary source
    RGD:1304796
    See related
    Ensembl:ENSRNOG00000008566 AllianceGenome:RGD:1304796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL15 (mitochondrial ribosomal protein L15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 333.9), Heart (RPKM 309.8) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mrpl15 in Genome Data Viewer
    Location:
    5q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (19527745..19539061)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (14729961..14741276)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (14609656..14620965)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A1 Neighboring gene lysophospholipase 1 Neighboring gene uncharacterized LOC102552817 Neighboring gene uncharacterized LOC120102814 Neighboring gene SRY-box transcription factor 17

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    3. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    large ribosomal subunit protein uL15m
    Names
    39S ribosomal protein L15, mitochondrial
    NP_001100103.1
    NP_001385932.1
    NP_001385936.1
    NP_001385937.1
    NP_001385938.1
    XP_063143343.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106633.2 → NP_001100103.1  large ribosomal subunit protein uL15m isoform 2

      See identical proteins and their annotated locations for NP_001100103.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JFJ4, D4A4A7, D4A4B1
      Related
      ENSRNOP00000011619.5, ENSRNOT00000011619.8
      Conserved Domains (1) summary
      pfam00828
      Location:52 → 175
      Ribosomal_L18e; Ribosomal protein L18e/L15

    2. NM_001399003.1 → NP_001385932.1  large ribosomal subunit protein uL15m isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A254, A6JFJ5
      Related
      ENSRNOP00000085368.1, ENSRNOT00000117082.1
      Conserved Domains (1) summary
      pfam00828
      Location:52 → 175
      Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

    3. NM_001399007.1 → NP_001385936.1  large ribosomal subunit protein uL15m isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    4. NM_001399008.1 → NP_001385937.1  large ribosomal subunit protein uL15m isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    5. NM_001399009.1 → NP_001385938.1  large ribosomal subunit protein uL15m isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K9B4
      Related
      ENSRNOP00000074933.2, ENSRNOT00000085621.2
      Conserved Domains (1) summary
      pfam00828
      Location:52 → 140
      Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

    RNA

    1. NR_174148.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      19527745..19539061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287273.1 → XP_063143343.1  large ribosomal subunit protein uL15m isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9C7, A6JFJ6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools