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    Trim43a tripartite motif-containing 43A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300884, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Trim43aprovided by RGD
    Official Full Name
    tripartite motif-containing 43Aprovided by RGD
    Primary source
    RGD:1561074
    See related
    Ensembl:ENSRNOG00000010699 AllianceGenome:RGD:1561074
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561074
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. Orthologous to several human genes including TRIM43 (tripartite motif containing 43). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 10.7), Brain (RPKM 4.1) and 9 other tissues See more
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    Genomic context

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    See Trim43a in Genome Data Viewer
    Location:
    8q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (98425912..98478569)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (89562568..89568716)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (96389303..96401465)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein Neighboring gene small nucleolar RNA SNORD50 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein, pseudogene 2 Neighboring gene zinc finger protein 949 Neighboring gene small nucleolar RNA SNORD50 Neighboring gene similar to RIKEN cDNA 4930579C12 gene Neighboring gene BCL2-related protein A1 Neighboring gene ribosomal protein S16, pseudogene 7 Neighboring gene methenyltetrahydrofolate synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing 43-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142944.1 → NP_001136416.1  tripartite motif-containing 43-like

      See identical proteins and their annotated locations for NP_001136416.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZLN6
      Related
      ENSRNOP00000046722.3, ENSRNOT00000044521.4
      Conserved Domains (3) summary
      cd00162
      Location:14 → 58
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:87 → 126
      zf-B_box; B-box zinc finger
      cl02614
      Location:335 → 446
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      98425912..98478569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265197.1 → XP_063121267.1  tripartite motif-containing 43-like isoform X2

    2. XM_063265195.1 → XP_063121265.1  tripartite motif-containing 43-like isoform X1

    3. XM_063265194.1 → XP_063121264.1  tripartite motif-containing 43-like isoform X1

    4. XM_063265196.1 → XP_063121266.1  tripartite motif-containing 43-like isoform X1

    RNA

    1. XR_010053952.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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