Tspan33 tetraspanin 33 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tspan33provided by RGD
Official Full Name: tetraspanin 33provided by RGD
Primary source: RGD:1560915
See related: Ensembl:ENSRNOG00000007900 AllianceGenome:RGD:1560915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560915
Summary: Predicted to enable enzyme binding activity. Predicted to be involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Predicted to be located in cell surface and tetraspanin-enriched microdomain. Predicted to be part of pore complex. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN33 (tetraspanin 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 222.9), Spleen (RPKM 182.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (59270713..59294249)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (58305378..58330013)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (56981283..57005866)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of pore complex	ISO Inferred from Sequence Orthology more info
located_in tetraspanin-enriched microdomain	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tetraspanin-33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109227.1 → NP_001102697.1 tetraspanin-33

See identical proteins and their annotated locations for NP_001102697.1

Status: PROVISIONAL

Source sequence(s)

CH473959

UniProtKB/TrEMBL

A6IEE5, D3Z967

Related

ENSRNOP00000010989.3, ENSRNOT00000010989.5

Conserved Domains (1) summary

cd03158
Location:116 → 236

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

59270713..59294249

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236227.4 → XP_006236289.1 tetraspanin-33 isoform X1

Conserved Domains (1) summary

cd03158
Location:115 → 235

penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
XM_039108118.2 → XP_038964046.1 tetraspanin-33 isoform X4

Conserved Domains (1) summary

pfam00335
Location:22 → 145

Tetraspannin; Tetraspanin family
XM_063286495.1 → XP_063142565.1 tetraspanin-33 isoform X2
XM_063286496.1 → XP_063142566.1 tetraspanin-33 isoform X3