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    Oasl2 2'-5' oligoadenylate synthetase-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304549, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Oasl2provided by RGD
    Official Full Name
    2'-5' oligoadenylate synthetase-like 2provided by RGD
    Primary source
    RGD:1307351
    See related
    Ensembl:ENSRNOG00000028814 AllianceGenome:RGD:1307351
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Predicted to be involved in defense response to virus; negative regulation of viral genome replication; and regulation of ribonuclease activity. Predicted to be active in cytosol; membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 131.5), Spleen (RPKM 112.2) and 9 other tissues See more
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    Genomic context

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    Location:
    12q16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47369829..47383337, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41710072..41722687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47470074..47483131, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene HNF1 homeobox A Neighboring gene similar to human chromosome 12 open reading frame 43 Neighboring gene uncharacterized LOC134481304 Neighboring gene 2'-5'-oligoadenylate synthetase-like Neighboring gene uncharacterized LOC120096007 Neighboring gene RIKEN cDNA 4930519G04 gene like Neighboring gene small nucleolar RNA SNORA26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. Perelygin AA, et al. J Mol Evol, 2006 Oct. PMID 17024523
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2'-5'-oligoadenylate synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2'-5'-oligoadenylate synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2'-5'-oligoadenylate synthetase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2'-5'-oligoadenylate synthase-like protein 2
    Names
    54 kDa 2'-5'-oligoadenylate synthase-like protein 2
    NP_001009682.1
    XP_008767549.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009682.1 → NP_001009682.1  2'-5'-oligoadenylate synthase-like protein 2

      See identical proteins and their annotated locations for NP_001009682.1

      Status: PROVISIONAL

      Source sequence(s)
      AY237116
      UniProtKB/Swiss-Prot
      Q5MYT9
      Conserved Domains (4) summary
      cd05400
      Location:29 → 214
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      cd01811
      Location:359 → 432
      Ubl1_OASL; ubiquitin-like (Ubl) domain 1 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
      cd16103
      Location:438 → 509
      Ubl2_OASL; ubiquitin-like (Ubl) domain 2 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins
      pfam10421
      Location:170 → 347
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47369829..47383337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769327.4 → XP_008767549.1  2'-5'-oligoadenylate synthase-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A140TA92
      Related
      ENSRNOP00000001600.6
      Conserved Domains (5) summary
      cd05400
      Location:29 → 214
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      cd01811
      Location:351 → 430
      OASL_repeat1; 2'-5' oligoadenylate synthetase-like protein, repeat 1 of 2
      smart00213
      Location:431 → 499
      UBQ; Ubiquitin homologues
      pfam10421
      Location:169 → 346
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl00155
      Location:438 → 499
      UBQ; Ubiquitin-like proteins

    RNA

    1. XR_010056394.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5MYT9.1 GenPept UniProtKB/Swiss-Prot:Q5MYT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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