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    Coprs coordinator of PRMT5 and differentiation stimulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290925, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Coprsprovided by RGD
    Official Full Name
    coordinator of PRMT5 and differentiation stimulatorprovided by RGD
    Primary source
    RGD:1565675
    See related
    Ensembl:ENSRNOG00000000111 AllianceGenome:RGD:1565675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Copr5; RGD1565675
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in histone H4-R3 methylation and muscle organ development. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human COPRS (coordinator of PRMT5 and differentiation stimulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 133.7), Brain (RPKM 92.4) and 9 other tissues See more
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    Genomic context

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    Location:
    16q12.5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82423426..82428821)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (75721264..75726375)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (80826681..80831791)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene testis development related protein Neighboring gene F-box protein 25 Neighboring gene chromosome alignment maintaining phosphoprotein 1 Neighboring gene ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Paul C, et al. Cell Death Differ, 2012 May. PMID 22193545, Free PMC Article
    2. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. Lacroix M, et al. EMBO Rep, 2008 May. PMID 18404153, Free PMC Article
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coordinator of PRMT5 and differentiation stimulator
    Names
    cooperator of PRMT5
    coordinator of PRMT5, differentiation stimulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169121.1 → NP_001162592.1  coordinator of PRMT5 and differentiation stimulator

      Status: VALIDATED

      Source sequence(s)
      CB614079
      UniProtKB/TrEMBL
      A6IWF3
      Related
      ENSRNOP00000000123.5, ENSRNOT00000000123.6
      Conserved Domains (1) summary
      pfam15340
      Location:24 → 173
      COPR5; Cooperator of PRMT5 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      82423426..82428821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275264.1 → XP_063131334.1  coordinator of PRMT5 and differentiation stimulator isoform X1

      UniProtKB/TrEMBL
      A6IWF4, D3ZB92
    Nucleotide Protein Strain
    Heading Accession and Version

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