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    Fbp1 fructose-bisphosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24362, updated on 5-Jun-2021

    Summary

    Official Symbol
    Fbp1provided by RGD
    Official Full Name
    fructose-bisphosphatase 1provided by RGD
    Primary source
    RGD:2595
    See related
    Ensembl:ENSRNOG00000017597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fdp
    Summary
    catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in gluconeogenesis [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 3334.2), Liver (RPKM 2280.7) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Fbp1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (2207271..2230076)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (396175..417480, complement)

    Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene FA complementation group C Neighboring gene microRNA 23b Neighboring gene aminopeptidase O Neighboring gene uncharacterized LOC102551048 Neighboring gene zinc finger protein 431-like Neighboring gene zinc finger protein 431-like Neighboring gene fructose-bisphosphatase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables AMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose 1,6-bisphosphate 1-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose 1,6-bisphosphate 1-phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables monosaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to magnesium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to magnesium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sucrose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fructose-1,6-bisphosphatase 1
    Names
    D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
    FBPase 1
    Fructose-16- biphosphatase
    fructose-1,6- biphosphatase 1
    liver FBPase
    NP_036690.2
    XP_038951270.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012558.3NP_036690.2  fructose-1,6-bisphosphatase 1

      See identical proteins and their annotated locations for NP_036690.2

      Status: VALIDATED

      Source sequence(s)
      BC078894, BC078895
      UniProtKB/Swiss-Prot
      P19112
      Related
      ENSRNOP00000023685.5, ENSRNOT00000023685.6
      Conserved Domains (1) summary
      cd00354
      Location:18332
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

      Range
      2207271..2230076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095342.1XP_038951270.1  fructose-1,6-bisphosphatase 1 isoform X1

      Conserved Domains (1) summary
      cd00354
      Location:1248
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
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