Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabra5provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit alpha 5provided by RGD
Primary source: RGD:61859
See related: Ensembl:ENSRNOG00000010803 AllianceGenome:RGD:61859
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA receptor binding activity; GABA-A receptor activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in brain development and chemical synaptic transmission. Located in dendrite and neuronal cell body membrane. Part of receptor complex. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 153.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (117404446..117517424, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (108268728..108381670, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (112833941..112947482, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alteration of the alpha5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model.
Title: Alteration of the α5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model.
Positive Allosteric Modulation of alpha5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle.
Title: Positive Allosteric Modulation of α5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle.
Sex-dependent pronociceptive role of spinal alpha5 -GABAA receptor and its epigenetic regulation in neuropathic rodents.
Title: Sex-dependent pronociceptive role of spinal α(5) -GABA(A) receptor and its epigenetic regulation in neuropathic rodents.
Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A alpha5 function produces memory impairment.
Title: Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A α5 function produces memory impairment.
Gabra5 receptors play a key role in the modulation of sweetened alcohol cue-induced reinstatement.
Title: α5GABA(A) subunit-containing receptors and sweetened alcohol cue-induced reinstatement and active sweetened alcohol self-administration in male rats.
Gabra5 overexpression increased tonic GABA currents and normalized aberrant pyramidal cell activity in the ventral hippocampus.
Title: Modulation of extrasynaptic GABA(A) alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner.
In the present study, the GABAA receptor alpha5 subunit gene expression in hippocampus and pilocarpine-induced epileptic behavior were investigated in the rat offspring prenatally exposed to restraint stress on E15-E17.
Title: Effect of prenatal stress on ɑ5 GABA(A) receptor subunit gene expression in hippocampus and pilocarpine induced seizure in rats.
decreases in the alpha5 subunit of the GABAA receptor may be important in mediating the sympatho-excitation observed in both hypertension and pregnancy.
Title: Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats.
Single unilateral infusion of NMDA at mild dose into the hippocampal formation induced chronic, focal neurodegeneration accompanied by severe and progressive neuroinflammation and affected preferentially principal neurons; GluN1 and GluN2B subunits of NMDA receptor were significantly upregulated up to 3 days after the NMDA infusion, while GABAA alpha5 subunit was downregulated at 30 days after the lesion
Title: Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits.
In a chronic pain model, alpha5-GABAA receptors play a role in the loss of GABAergic inhibition and contribute to secondary allodynia.
Title: The α5 subunit containing GABAA receptors contribute to chronic pain.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	TAS Traceable Author Statement more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner ear receptor cell development	ISO Inferred from Sequence Orthology more info
involved_in innervation	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GABA-A receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit alpha-5

Names: GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid type A receptor alpha 5 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017295.2 → NP_058991.2 gamma-aminobutyric acid receptor subunit alpha-5 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P19969

UniProtKB/TrEMBL

A6KD37, A6KD38

Related

ENSRNOP00000072389.1, ENSRNOT00000083894.2

Conserved Domains (2) summary

TIGR00860
Location:15 → 450

LIC; Cation transporter family protein

cd19038
Location:58 → 256

LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

117404446..117517424 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589075.3 → XP_017444564.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

UniProtKB/Swiss-Prot

P19969

UniProtKB/TrEMBL

A6KD37, A6KD38

Conserved Domains (2) summary

TIGR00860
Location:15 → 450

LIC; Cation transporter family protein

cd19038
Location:58 → 256

LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
XM_017589074.3 → XP_017444563.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

UniProtKB/Swiss-Prot

P19969

UniProtKB/TrEMBL

A6KD37, A6KD38

Conserved Domains (2) summary

TIGR00860
Location:15 → 450

LIC; Cation transporter family protein

cd19038
Location:58 → 256

LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
XM_039109851.2 → XP_038965779.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X2

Conserved Domains (3) summary

TIGR00860
Location:1 → 359

LIC; Cation transporter family protein

cd03558
Location:82 → 96

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:1 → 165

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_017589073.3 → XP_017444562.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

UniProtKB/Swiss-Prot

P19969

UniProtKB/TrEMBL

A6KD37, A6KD38

Conserved Domains (2) summary

TIGR00860
Location:15 → 450

LIC; Cation transporter family protein

cd19038
Location:58 → 256

LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
XM_017589076.2 → XP_017444565.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

UniProtKB/Swiss-Prot

P19969

UniProtKB/TrEMBL

A6KD37, A6KD38

Conserved Domains (2) summary

TIGR00860
Location:15 → 450

LIC; Cation transporter family protein

cd19038
Location:58 → 256

LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)
XM_039109837.1 → XP_038965765.1 gamma-aminobutyric acid receptor subunit alpha-5 isoform X1

UniProtKB/Swiss-Prot

P19969

UniProtKB/TrEMBL

A6KD37, A6KD38

Conserved Domains (2) summary

TIGR00860
Location:15 → 450

LIC; Cation transporter family protein

cd19038
Location:58 → 256

LGIC_ECD_GABAAR_A5; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-5 (GABAAR-A5 or GABRA5)