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    Ighe immunoglobulin heavy constant epsilon [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299351, updated on 2-May-2024

    Summary

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    Official Symbol
    Igheprovided by RGD
    Official Full Name
    immunoglobulin heavy constant epsilonprovided by RGD
    Primary source
    RGD:2880
    See related
    AllianceGenome:RGD:2880
    Gene type
    other
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IGH2
    Summary
    Orthologous to human IGHE (immunoglobulin heavy constant epsilon). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    not in current annotation release
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    Genomic context

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    See Ighe in Genome Data Viewer
    Location:
    6q32
    Annotation release Status Assembly Chr Location
    106 latest, but not current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (138066728..138068606, complement)
    106 latest, but not current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (129872683..129874561, complement)

    Bibliography

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    Related articles in PubMed

    1. A cloned cDNA probe for rat immunoglobulin epsilon heavy chain: construction, identification, and DNA sequence. Kindsvogel WR, et al. DNA, 1982. PMID 6820340
    2. Characterization and molecular cloning of the mRNA for the heavy (epsilon) chain of rat immunoglobulin E. Hellman L, et al. Proc Natl Acad Sci U S A, 1982 Feb. PMID 6803238, Free PMC Article
    3. Structure and evolution of the heavy chain from rat immunoglobulin E. Hellman L, et al. Nucleic Acids Res, 1982 Oct 11. PMID 6292865, Free PMC Article
    4. Rat immunoglobulin E heavy chain locus. Steen ML, et al. J Mol Biol, 1984 Jul 25. PMID 6086939
    5. A simple and precise aberrant translocation of the rat c-myc gene into the epsilon-heavy chain switch region of the IgE-producing immunocytoma, IR162. Tian SS, et al. J Biol Chem, 1989 Jan 25. PMID 2492284

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Other Names

    • Ig epsilon chain C region
    • immunoglobulin heavy chain (epsilon polypeptide)

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Fc receptor-mediated immune complex endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune memory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibody-dependent cellular cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in eosinophil degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type 2 immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type I hypersensitivity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of IgE B cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01855.1 GenPept UniProtKB/Swiss-Prot:P01855

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