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    Tmem53 transmembrane protein 53 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313529, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tmem53provided by RGD
    Official Full Name
    transmembrane protein 53provided by RGD
    Primary source
    RGD:1307066
    See related
    Ensembl:ENSRNOG00000019186 AllianceGenome:RGD:1307066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307066
    Summary
    Predicted to be integral component of membrane. Orthologous to human TMEM53 (transmembrane protein 53). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 96.1), Adrenal (RPKM 81.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem53 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135958344..135974258)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130721780..130737692)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136112417..136127976)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U5 spliceosomal RNA Neighboring gene U5 spliceosomal RNA Neighboring gene armadillo-like helical domain containing 1 Neighboring gene ring finger protein 220 Neighboring gene uncharacterized LOC134486974 Neighboring gene ribosomal protein S13, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107964.1 → NP_001101434.1  transmembrane protein 53

      See identical proteins and their annotated locations for NP_001101434.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K1Q4, A6JZD3, A6JZD4, D3ZPB8
      Related
      ENSRNOP00000025990.4, ENSRNOT00000025990.7
      Conserved Domains (1) summary
      pfam05705
      Location:34 → 270
      DUF829; Eukaryotic protein of unknown function (DUF829)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135958344..135974258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109999.2 → XP_038965927.1  transmembrane protein 53 isoform X2

      Conserved Domains (1) summary
      pfam05705
      Location:13 → 199
      DUF829; Eukaryotic protein of unknown function (DUF829)

    2. XM_006238665.5 → XP_006238727.1  transmembrane protein 53 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1Q4, A0A8I6G340, A6JZD4
      Related
      ENSRNOP00000079317.1
      Conserved Domains (1) summary
      pfam05705
      Location:19 → 255
      DUF829; Eukaryotic protein of unknown function (DUF829)

    3. XM_017593389.3 → XP_017448878.1  transmembrane protein 53 isoform X2

      Conserved Domains (1) summary
      pfam05705
      Location:13 → 199
      DUF829; Eukaryotic protein of unknown function (DUF829)

    4. XM_039109997.2 → XP_038965925.1  transmembrane protein 53 isoform X2

      Conserved Domains (1) summary
      pfam05705
      Location:13 → 199
      DUF829; Eukaryotic protein of unknown function (DUF829)

    5. XM_017593390.3 → XP_017448879.1  transmembrane protein 53 isoform X2

      Conserved Domains (1) summary
      pfam05705
      Location:13 → 199
      DUF829; Eukaryotic protein of unknown function (DUF829)
    Nucleotide Protein Strain
    Heading Accession and Version

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