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    Fxr2 FMR1 autosomal homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287433, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fxr2provided by RGD
    Official Full Name
    FMR1 autosomal homolog 2provided by RGD
    Primary source
    RGD:1307011
    See related
    Ensembl:ENSRNOG00000011876 AllianceGenome:RGD:1307011
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fxr2h
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; protein dimerization activity; and translation regulator activity. Predicted to be involved in several processes, including positive regulation of response to DNA damage stimulus; regulation of filopodium assembly; and regulation of gene expression. Predicted to be located in several cellular components, including dendrite; glutamatergic synapse; and postsynapse. Predicted to be part of polysome. Predicted to be active in several cellular components, including dendrite; growth cone; and postsynaptic density. Orthologous to human FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 279.9), Heart (RPKM 242.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54849345..54869713)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54350577..54370964)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56237814..56257877)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480815 Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene SRY-box transcription factor 15 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene Cd68 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The functional significance of absence: the chromosomal segment harboring Tp53 is absent from the T55 rat radiation hybrid mapping panel. Behboudi A, et al. Genomics, 2002 Jun. PMID 12036299
    2. On the aggregation properties of FMRP--a link with the FXTAS syndrome? Sjekloća L, et al. FEBS J, 2011 Jun. PMID 21446998
    3. Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. Wang GX, et al. Elife, 2016 Oct 22. PMID 27770568, Free PMC Article
    4. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. Zhang Y, et al. EMBO J, 1995 Nov 1. PMID 7489725, Free PMC Article
    5. Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. Cook D, et al. PLoS One, 2011. PMID 22022532, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dentate gyrus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of long-term neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation at presynapse, modulating synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein FXR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100647.1 → NP_001094117.1  RNA-binding protein FXR2

      See identical proteins and their annotated locations for NP_001094117.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160929
      UniProtKB/TrEMBL
      A0A8J8YNR6, B1H2A6, F1M3Y6
      Conserved Domains (7) summary
      pfam12235
      Location:364 → 475
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16096
      Location:512 → 579
      FXR_C1; Fragile X-related 1 protein C-terminal region 2
      cd20473
      Location:13 → 67
      Tudor_Agenet_FXR2_rpt1; first Tudor-like Agenet domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd20476
      Location:69 → 136
      Tudor_Agenet_FXR2_rpt2; second Tudor-like Agenet domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd22505
      Location:133 → 209
      KH_I_FXR2_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd22508
      Location:228 → 290
      KH_I_FXR2_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd22511
      Location:291 → 368
      KH_I_FXR2_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54849345..54869713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085448.2 → XP_038941376.1  RNA-binding protein FXR2 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YNR6
      Related
      ENSRNOP00000016163.6
      Conserved Domains (7) summary
      pfam12235
      Location:363 → 474
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16096
      Location:511 → 578
      FXR_C1; Fragile X-related 1 protein C-terminal region 2
      cd20476
      Location:68 → 135
      Tudor_Agenet_FXR2_rpt2; second Tudor-like Agenet domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd22505
      Location:132 → 208
      KH_I_FXR2_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd22508
      Location:227 → 289
      KH_I_FXR2_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd22511
      Location:290 → 367
      KH_I_FXR2_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cl02573
      Location:44 → 66
      Tudor_SF; Tudor domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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