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    Kyat3 kynurenine aminotransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 541589, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Kyat3provided by RGD
    Official Full Name
    kynurenine aminotransferase 3provided by RGD
    Primary source
    RGD:1359262
    See related
    Ensembl:ENSRNOG00000043426 AllianceGenome:RGD:1359262
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kat3; Ccbl2
    Summary
    Predicted to enable kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; and protein homodimerization activity. Predicted to be involved in 2-oxoglutarate metabolic process and kynurenine metabolic process. Predicted to be active in mitochondrion. Orthologous to human KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 779.5), Kidney (RPKM 151.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q44
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (234362306..234407646)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (231701881..231747462)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248644473..248690289)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 1, pseudogene 1 Neighboring gene guanylate binding protein 6, pseudogene 2 Neighboring gene uncharacterized LOC108350125 Neighboring gene RNA, U6 small nuclear 503 Neighboring gene general transcription factor IIB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and structural properties of mouse kynurenine aminotransferase III. Han Q, et al. Mol Cell Biol, 2009 Feb. PMID 19029248, Free PMC Article
    2. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Han Q, et al. Cell Mol Life Sci, 2010 Feb. PMID 19826765, Free PMC Article
    3. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu P, et al. Gene, 2006 Jan 3. PMID 16376499
    4. The kynurenine pathway and neurodegenerative disease. Maddison DC, et al. Semin Cell Dev Biol, 2015 Apr. PMID 25773161
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-glyoxylate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-glyoxylate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kynurenine-glyoxylate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kynurenine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine--oxoglutarate transaminase 3
    Names
    KATIII
    cysteine conjugate-beta lyase 2
    cysteine-S-conjugate beta-lyase 2
    kynurenine aminotransferase III
    kynurenine aminotransferase III-like
    kynurenine--glyoxylate transaminase
    kynurenine--oxoglutarate transaminase III
    NP_001015037.1
    XP_038958899.1
    XP_038958900.1
    XP_038958902.1
    XP_038958903.1
    XP_038958904.1
    XP_038958905.1
    XP_063138487.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015037.1 → NP_001015037.1  kynurenine--oxoglutarate transaminase 3

      See identical proteins and their annotated locations for NP_001015037.1

      Status: PROVISIONAL

      Source sequence(s)
      AY955395
      UniProtKB/Swiss-Prot
      Q58FK9
      Related
      ENSRNOP00000083094.1, ENSRNOT00000101068.1
      Conserved Domains (2) summary
      cd00609
      Location:66 → 447
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK07777
      Location:44 → 452
      PRK07777; aminotransferase; Validated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      234362306..234407646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102972.2 → XP_038958900.1  kynurenine--oxoglutarate transaminase 3 isoform X2

      Conserved Domains (1) summary
      PRK07777
      Location:10 → 418
      PRK07777; putative succinyldiaminopimelate transaminase DapC

    2. XM_039102977.2 → XP_038958905.1  kynurenine--oxoglutarate transaminase 3 isoform X4

      Conserved Domains (1) summary
      PRK08912
      Location:3 → 298
      PRK08912; aminotransferase

    3. XM_039102971.2 → XP_038958899.1  kynurenine--oxoglutarate transaminase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUT0, A6HW71
      Conserved Domains (1) summary
      PRK07777
      Location:44 → 452
      PRK07777; putative succinyldiaminopimelate transaminase DapC

    4. XM_063282417.1 → XP_063138487.1  kynurenine--oxoglutarate transaminase 3 isoform X2

    5. XM_039102974.2 → XP_038958902.1  kynurenine--oxoglutarate transaminase 3 isoform X2

      Conserved Domains (1) summary
      PRK07777
      Location:10 → 418
      PRK07777; putative succinyldiaminopimelate transaminase DapC

    6. XM_039102975.2 → XP_038958903.1  kynurenine--oxoglutarate transaminase 3 isoform X2

      Conserved Domains (1) summary
      PRK07777
      Location:10 → 418
      PRK07777; putative succinyldiaminopimelate transaminase DapC

    7. XM_039102976.2 → XP_038958904.1  kynurenine--oxoglutarate transaminase 3 isoform X3

      Conserved Domains (1) summary
      PRK08912
      Location:17 → 410
      PRK08912; aminotransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58FK9.1 GenPept UniProtKB/Swiss-Prot:Q58FK9

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