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    Prxl2c peroxiredoxin like 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498685, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Prxl2cprovided by RGD
    Official Full Name
    peroxiredoxin like 2Cprovided by RGD
    Primary source
    RGD:1589650
    See related
    Ensembl:ENSRNOG00000018886 AllianceGenome:RGD:1589650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aaed1
    Summary
    Predicted to enable antioxidant activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. Orthologous to human PRXL2C (peroxiredoxin like 2C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 95.0), Heart (RPKM 89.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (817932..849965)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (812199..839536)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1798224..1830011, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3-like Neighboring gene cathepsin L Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA serine (anticodon AGA) 40 Neighboring gene cell division cycle 14B Neighboring gene uncharacterized LOC134482653 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AAED1 modulates proliferation and glycolysis in gastric cancer. Zhang B, et al. Oncol Rep, 2018 Aug. PMID 29901208
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxiredoxin-like 2C
    Names
    AhpC/TSA antioxidant enzyme domain containing 1
    thioredoxin-like protein AAED1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399210.1 → NP_001386139.1  peroxiredoxin-like 2C isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6G5D2, A6KQE1
      Related
      ENSRNOP00000079468.1, ENSRNOT00000109028.1
      Conserved Domains (1) summary
      cd02970
      Location:34 → 195
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    2. NM_001399211.1 → NP_001386140.1  peroxiredoxin-like 2C isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6A506
      Related
      ENSRNOP00000086014.1, ENSRNOT00000104207.1
      Conserved Domains (1) summary
      cd02970
      Location:34 → 168
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      817932..849965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095988.2 → XP_038951916.1  peroxiredoxin-like 2C isoform X2

      Conserved Domains (1) summary
      cd02970
      Location:34 → 134
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    2. XM_063276679.1 → XP_063132749.1  peroxiredoxin-like 2C isoform X3

      UniProtKB/TrEMBL
      A6KQD9, D3ZAK1

    3. XM_039095987.2 → XP_038951915.1  peroxiredoxin-like 2C isoform X1

      Conserved Domains (1) summary
      cd02970
      Location:34 → 192
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RNA

    1. XR_010058909.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109114.1: Suppressed sequence

      Description
      NM_001109114.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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