Dele1 DAP3 binding cell death enhancer 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dele1provided by RGD
Official Full Name: DAP3 binding cell death enhancer 1provided by RGD
Primary source: RGD:735029
See related: Ensembl:ENSRNOG00000019276 AllianceGenome:RGD:735029
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dele; DELE1(L); RGD735029
Summary: Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in HRI-mediated signaling; extrinsic apoptotic signaling pathway via death domain receptors; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 333.4), Kidney (RPKM 246.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (30325369..30349285)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (30085093..30098105)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (31396897..31409914)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functionally characterizes the human homolog as a DAP3-binding protein involved in apoptosis mediated by death receptors.
Title: Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134338 (e-PCR)
- UniSTS:217620

RH130159 (e-PCR)
- UniSTS:213446

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in HRI-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in HRI-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrated stress response signaling	ISO Inferred from Sequence Orthology more info
involved_in integrated stress response signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion starvation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DAP3-binding cell death enhancer 1

Names: DAP3-binding cell death enhancer 1, long form; SEL1 domain containing protein RGD735029; death ligand signal enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199493.1 → NP_955787.1 DAP3-binding cell death enhancer 1

See identical proteins and their annotated locations for NP_955787.1

Status: PROVISIONAL

Source sequence(s)

BC064660

Related

ENSRNOP00000026273.4, ENSRNOT00000026273.8

Conserved Domains (3) summary

smart00671
Location:278 → 313

SEL1; Sel1-like repeats

COG0790
Location:260 → 432

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:261 → 290

SLR; SLR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

30325369..30349285

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254634.5 → XP_006254696.1 DAP3-binding cell death enhancer 1 isoform X1

Conserved Domains (3) summary

smart00671
Location:284 → 319

SEL1; Sel1-like repeats

COG0790
Location:266 → 438

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:267 → 296

SLR; SLR repeat [structural motif]
XM_063277368.1 → XP_063133438.1 DAP3-binding cell death enhancer 1 isoform X2

UniProtKB/Swiss-Prot

G3V8I7, P60924