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    Eef1akmt2 EEF1A lysine methyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361664, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Eef1akmt2provided by RGD
    Official Full Name
    EEF1A lysine methyltransferase 2provided by RGD
    Primary source
    RGD:1306300
    See related
    Ensembl:ENSRNOG00000017137 AllianceGenome:RGD:1306300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mettl10; RGD1306300
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Predicted to be located in cytosol and nuclear body. Predicted to be active in cytoplasm. Orthologous to human EEF1AKMT2 (EEF1A lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 77.6), Brain (RPKM 76.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eef1akmt2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (197009919..197071033, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187616156..187640934, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204830008..204855627, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene uncharacterized LOC120099945 Neighboring gene family with sequence similarity 53, member B Neighboring gene uncharacterized LOC134483949 Neighboring gene uncharacterized LOC102552031 Neighboring gene abraxas 2, BRISC complex subunit Neighboring gene ribosomal protein S23, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. Shimazu T, et al. PLoS One, 2014. PMID 25144183, Free PMC Article
    2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EEF1A lysine methyltransferase 2
    Names
    methyltransferase like 10
    methyltransferase-like protein 10
    protein-lysine N-methyltransferase METTL10
    NP_001380625.1
    XP_017444917.1
    XP_017444919.1
    XP_038939222.1
    XP_038939225.1
    XP_038939232.1
    XP_038939237.1
    XP_063123985.1
    XP_063123990.1
    XP_063124004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393696.1 → NP_001380625.1  EEF1A lysine methyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HX02, D4A7N2
      Related
      ENSRNOP00000023121.5, ENSRNOT00000023121.5
      Conserved Domains (1) summary
      pfam13847
      Location:80 → 214
      Methyltransf_31; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      197009919..197071033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083309.1 → XP_038939237.1  EEF1A lysine methyltransferase 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JVV2, A0A8I5ZLB6
      Related
      ENSRNOP00000078655.1, ENSRNOT00000113421.1

    2. XM_039083294.2 → XP_038939222.1  EEF1A lysine methyltransferase 2 isoform X2

    3. XM_039083297.2 → XP_038939225.1  EEF1A lysine methyltransferase 2 isoform X5

      Conserved Domains (1) summary
      pfam13649
      Location:83 → 127
      Methyltransf_25; Methyltransferase domain

    4. XM_039083304.1 → XP_038939232.1  EEF1A lysine methyltransferase 2 isoform X6

    5. XM_017589428.3 → XP_017444917.1  EEF1A lysine methyltransferase 2 isoform X1

    6. XM_063267934.1 → XP_063124004.1  EEF1A lysine methyltransferase 2 isoform X7

    7. XM_063267915.1 → XP_063123985.1  EEF1A lysine methyltransferase 2 isoform X3

    8. XM_017589430.3 → XP_017444919.1  EEF1A lysine methyltransferase 2 isoform X3

      Conserved Domains (1) summary
      pfam13847
      Location:16 → 150
      Methyltransf_31; Methyltransferase domain

    9. XM_063267920.1 → XP_063123990.1  EEF1A lysine methyltransferase 2 isoform X4

    RNA

    1. XR_010054815.1 RNA Sequence

    2. XR_350777.5 RNA Sequence

    3. XR_005488872.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108504.1: Suppressed sequence

      Description
      NM_001108504.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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