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    Osbpl3 oxysterol binding protein-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362360, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Osbpl3provided by RGD
    Official Full Name
    oxysterol binding protein-like 3provided by RGD
    Primary source
    RGD:1564287
    See related
    Ensembl:ENSRNOG00000010011 AllianceGenome:RGD:1564287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564287
    Summary
    Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to be involved in sterol transport. Predicted to be located in nuclear membrane. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBPL3 (oxysterol binding protein like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 100.9), Thymus (RPKM 43.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl3 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (80677383..80854169, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (79346583..79523523, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (80025453..80202532, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene protein associated with LIN7 2, MAGUK p55 family member Neighboring gene gasdermin E Neighboring gene uncharacterized LOC120102268 Neighboring gene uncharacterized LOC134486672

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. Lehto M, et al. Cell Tissue Res, 2004 Jan. PMID 14593528
    2. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article
    3. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427811.2 → NP_001414740.1  oxysterol-binding protein-related protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AC59, D3ZHZ3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      80677383..80854169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762935.4 → XP_008761157.1  oxysterol-binding protein-related protein 3 isoform X4

      See identical proteins and their annotated locations for XP_008761157.1

      UniProtKB/TrEMBL
      A0A8I6AC59
      Conserved Domains (3) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:54 → 141
      PH; PH domain
      pfam01237
      Location:459 → 793
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_008762934.4 → XP_008761156.1  oxysterol-binding protein-related protein 3 isoform X2

      See identical proteins and their annotated locations for XP_008761156.1

      UniProtKB/TrEMBL
      A0A8I6AC59, A0A8I6GM73, A6K0M1
      Related
      ENSRNOP00000097750.1
      Conserved Domains (4) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:54 → 141
      PH; PH domain
      pfam01237
      Location:495 → 829
      Oxysterol_BP; Oxysterol-binding protein
      cl00155
      Location:334 → 402
      UBQ; Ubiquitin-like proteins

    3. XM_006236519.5 → XP_006236581.1  oxysterol-binding protein-related protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006236581.1

      UniProtKB/TrEMBL
      A0A8I5ZPL4, A0A8I6AC59
      Related
      ENSRNOP00000080185.1
      Conserved Domains (3) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:54 → 141
      PH; PH domain
      pfam01237
      Location:490 → 824
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_017592994.3 → XP_017448483.1  oxysterol-binding protein-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AC59, D3ZHZ3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_063286257.1 → XP_063142327.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC59, A0A8I6GM73, A6K0M1

    6. XM_063286259.1 → XP_063142329.1  oxysterol-binding protein-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZPL4, A0A8I6AC59

    7. XM_006236516.5 → XP_006236578.1  oxysterol-binding protein-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006236578.1

      UniProtKB/TrEMBL
      A0A8I6AC59, D3ZHZ3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_039108672.2 → XP_038964600.1  oxysterol-binding protein-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AC59, D3ZHZ3
      Related
      ENSRNOP00000091685.1
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_063286261.1 → XP_063142331.1  oxysterol-binding protein-related protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AC59

    10. XM_063286258.1 → XP_063142328.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC59, A0A8I6GM73, A6K0M1

    11. XM_006236518.4 → XP_006236580.1  oxysterol-binding protein-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006236580.1

      UniProtKB/TrEMBL
      A0A8I6AC59, D3ZHZ3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    12. XM_063286260.1 → XP_063142330.1  oxysterol-binding protein-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZPL4, A0A8I6AC59

    13. XM_342683.10 → XP_342684.5  oxysterol-binding protein-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_342684.5

      UniProtKB/TrEMBL
      A0A8I6AC59, D3ZHZ3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version

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