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    B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305571, updated on 11-Apr-2024

    Summary

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    Official Symbol
    B3gnt2provided by RGD
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2provided by RGD
    Primary source
    RGD:1310077
    See related
    Ensembl:ENSRNOG00000009267 AllianceGenome:RGD:1310077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B3gnt1
    Summary
    Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process. Predicted to act upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and sensory perception of smell. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Orthologous to human B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 306.5), Spleen (RPKM 225.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B3gnt2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (101009682..101034507, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (96808473..96833674, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (107592336..107617189, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096692 Neighboring gene uncharacterized LOC102552091 Neighboring gene uncharacterized LOC102552343 Neighboring gene uncharacterized LOC102552414 Neighboring gene uncharacterized LOC134481876 Neighboring gene copper metabolism domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. β3GnT2 null mice exhibit defective accessory olfactory bulb innervation. Henion TR, et al. Mol Cell Neurosci, 2013 Jan. PMID 23006775
    2. A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. Zhou D, et al. Proc Natl Acad Sci U S A, 1999 Jan 19. PMID 9892646, Free PMC Article
    3. Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. Shiraishi N, et al. J Biol Chem, 2001 Feb 2. PMID 11042166
    4. B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan. Praissman JL, et al. Elife, 2014 Oct 3. PMID 25279697, Free PMC Article
    5. Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons. Henion TR, et al. J Neurosci, 2005 Feb 23. PMID 15728829, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
    Names
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
    NP_001100710.1
    XP_006251617.1
    XP_006251618.1
    XP_008768649.1
    XP_063129336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107240.1 → NP_001100710.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

      See identical proteins and their annotated locations for NP_001100710.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473996
      UniProtKB/TrEMBL
      A6JQ57, D3ZEF9
      Related
      ENSRNOP00000012286.3, ENSRNOT00000012286.5
      Conserved Domains (1) summary
      cl21608
      Location:156 → 345
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      101009682..101034507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251556.5 → XP_006251618.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006251618.1

      UniProtKB/TrEMBL
      A6JQ57, D3ZEF9
      Conserved Domains (1) summary
      cl21608
      Location:156 → 345
      Galactosyl_T; Galactosyltransferase

    2. XM_006251555.3 → XP_006251617.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006251617.1

      UniProtKB/TrEMBL
      A6JQ57, D3ZEF9
      Conserved Domains (1) summary
      cl21608
      Location:156 → 345
      Galactosyl_T; Galactosyltransferase

    3. XM_008770427.4 → XP_008768649.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_008768649.1

      UniProtKB/TrEMBL
      A6JQ57, D3ZEF9
      Related
      ENSRNOP00000089888.1
      Conserved Domains (1) summary
      cl21608
      Location:156 → 345
      Galactosyl_T; Galactosyltransferase

    4. XM_063273266.1 → XP_063129336.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A6JQ57, D3ZEF9
    Nucleotide Protein Strain
    Heading Accession and Version

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