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    Ttll13 tubulin tyrosine ligase like 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308762, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ttll13provided by RGD
    Official Full Name
    tubulin tyrosine ligase like 13provided by RGD
    Primary source
    RGD:1310399
    See related
    Ensembl:ENSRNOG00000056362 AllianceGenome:RGD:1310399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310399
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to be active in cilium. Orthologous to human TTLL13 (tubulin tyrosine ligase like 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 287.6), Thymus (RPKM 43.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttll13 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143601777..143622344)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134197801..134213083)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142034423..142050071)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene semaphorin 4B Neighboring gene calcium and integrin binding 1 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene neugrin, neurite outgrowth associated Neighboring gene VPS33B, late endosome and lysosome associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189386

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polyglutamylase TTLL13
    Names
    tubulin tyrosine ligase-like family, member 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134962.1 → NP_001128434.1  tubulin polyglutamylase TTLL13

      See identical proteins and their annotated locations for NP_001128434.1

      Status: VALIDATED

      Source sequence(s)
      BC169015
      UniProtKB/TrEMBL
      B5DFD2
      Related
      ENSRNOP00000073642.2, ENSRNOT00000090006.2
      Conserved Domains (1) summary
      pfam03133
      Location:133 → 416
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143601777..143622344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262665.1 → XP_063118735.1  tubulin polyglutamylase TTLL13 isoform X1

      UniProtKB/TrEMBL
      B5DFD2

    2. XM_063262664.1 → XP_063118734.1  tubulin polyglutamylase TTLL13 isoform X1

      UniProtKB/TrEMBL
      B5DFD2

    3. XM_063262663.1 → XP_063118733.1  tubulin polyglutamylase TTLL13 isoform X1

      UniProtKB/TrEMBL
      B5DFD2

    4. XM_063262666.1 → XP_063118736.1  tubulin polyglutamylase TTLL13 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K619, A6JC91

    5. XM_063262670.1 → XP_063118740.1  tubulin polyglutamylase TTLL13 isoform X4

      UniProtKB/TrEMBL
      A6JC91

    6. XM_063262667.1 → XP_063118737.1  tubulin polyglutamylase TTLL13 isoform X3

    7. XM_063262675.1 → XP_063118745.1  tubulin polyglutamylase TTLL13 isoform X5

      UniProtKB/TrEMBL
      A6JC91

    8. XM_063262677.1 → XP_063118747.1  tubulin polyglutamylase TTLL13 isoform X6

    9. XM_063262678.1 → XP_063118748.1  tubulin polyglutamylase TTLL13 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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