Ugp2 UDP-glucose pyrophosphorylase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugp2provided by RGD
Official Full Name: UDP-glucose pyrophosphorylase 2provided by RGD
Primary source: RGD:1310210
See related: Ensembl:ENSRNOG00000008079 AllianceGenome:RGD:1310210
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables UTP:glucose-1-phosphate uridylyltransferase activity; glucose binding activity; and pyrimidine ribonucleotide binding activity. Involved in UDP-glucose metabolic process and glucose 1-phosphate metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 1998.6), Liver (RPKM 1031.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (99657637..99698573, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (95456330..95497483, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (106208174..106249322, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141780 (e-PCR)
- UniSTS:223773

Ugp2 (e-PCR), detects polymorphism
- UniSTS:498753

RH133427 (e-PCR)
- UniSTS:216710

BF402398 (e-PCR)
- UniSTS:245911

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables UTP-monosaccharide-1-phosphate uridylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables UTP:glucose-1-phosphate uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UTP:glucose-1-phosphate uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables UTP:glucose-1-phosphate uridylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glucose binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyrimidine ribonucleotide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in glucose 1-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: UTP--glucose-1-phosphate uridylyltransferase

NP_001019914.1

EC 2.7.7.9

XP_006251600.1

EC 2.7.7.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024743.1 → NP_001019914.1 UTP--glucose-1-phosphate uridylyltransferase

See identical proteins and their annotated locations for NP_001019914.1

Status: PROVISIONAL

Source sequence(s)

BC097369

UniProtKB/TrEMBL

A0A0G2K542, A0A9K3Y8H8, F1LQ84, Q4V8I9

Related

ENSRNOP00000063786.2, ENSRNOT00000067668.4

Conserved Domains (1) summary

pfam01704
Location:57 → 473

UDPGP; UTP--glucose-1-phosphate uridylyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

99657637..99698573 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251538.3 → XP_006251600.1 UTP--glucose-1-phosphate uridylyltransferase isoform X1

UniProtKB/TrEMBL

A0A0G2K542, A0A8I6G7V9

Related

ENSRNOP00000073284.2

Conserved Domains (1) summary

pfam01704
Location:46 → 462

UDPGP; UTP--glucose-1-phosphate uridylyltransferase