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    Vopp1 VOPP1 WW domain binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362374, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Vopp1provided by RGD
    Official Full Name
    VOPP1 WW domain binding proteinprovided by RGD
    Primary source
    RGD:1306494
    See related
    Ensembl:ENSRNOG00000006646 AllianceGenome:RGD:1306494
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ecop; RGD1306494
    Summary
    Predicted to be located in cytoplasmic vesicle membrane and endosome. Predicted to be integral component of organelle membrane. Orthologous to human VOPP1 (VOPP1 WW domain binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 333.5), Brain (RPKM 209.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vopp1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (88692784..88762903)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (87363678..87432747)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (88441067..88515141)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor pseudogene 111 Neighboring gene vomeronasal 1 receptor 88 Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene PIGY upstream open reading frame

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intracellular localization of GASP/ECOP/VOPP1. Baras A, et al. J Mol Histol, 2010 Apr. PMID 20571887
    2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WW domain binding protein VOPP1
    Names
    EGFR-coamplified and overexpressed protein
    VOPP1, WBP1/VOPP1 family member
    vesicular, overexpressed in cancer, prosurvival protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108630.1 → NP_001102100.1  WW domain binding protein VOPP1 precursor

      See identical proteins and their annotated locations for NP_001102100.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474011
      UniProtKB/Swiss-Prot
      B5DEK8
      UniProtKB/TrEMBL
      A0A8I6AIE2
      Related
      ENSRNOP00000008885.4, ENSRNOT00000008885.6
      Conserved Domains (1) summary
      cl25887
      Location:102 → 155
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      88692784..88762903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286275.1 → XP_063142345.1  WW domain binding protein VOPP1 isoform X3

      UniProtKB/TrEMBL
      A6K127

    2. XM_063286274.1 → XP_063142344.1  WW domain binding protein VOPP1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTM1

    3. XM_063286277.1 → XP_063142347.1  WW domain binding protein VOPP1 isoform X3

      UniProtKB/TrEMBL
      A6K127

    4. XM_006236578.5 → XP_006236640.1  WW domain binding protein VOPP1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIE2
      Related
      ENSRNOP00000092555.1
      Conserved Domains (1) summary
      cl25887
      Location:85 → 138
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    5. XM_063286276.1 → XP_063142346.1  WW domain binding protein VOPP1 isoform X3

      UniProtKB/TrEMBL
      A6K127
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DEK8.1 GenPept UniProtKB/Swiss-Prot:B5DEK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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