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    Ctdp1 CTD phosphatase subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291414, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ctdp1provided by RGD
    Official Full Name
    CTD phosphatase subunit 1provided by RGD
    Primary source
    RGD:1311755
    See related
    Ensembl:ENSRNOG00000061474 AllianceGenome:RGD:1311755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity; TFIIF-class transcription factor complex binding activity; and Tat protein binding activity. Involved in negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in microtubule cytoskeleton; midbody; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human CTDP1 (CTD phosphatase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 140.0), Thymus (RPKM 116.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctdp1 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (76129243..76193404, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73854277..73916232, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76922913..76985095, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098179 Neighboring gene potassium voltage-gated channel modifier subfamily G member 2 Neighboring gene uncharacterized LOC134482964 Neighboring gene uncharacterized LOC103694249 Neighboring gene uncharacterized LOC134482963 Neighboring gene nuclear factor of activated T-cells 1 Neighboring gene ATPase phospholipid transporting 9B (putative) Neighboring gene uncharacterized LOC134482965

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymerase II. Sakai S, et al. Life Sci, 2012 Oct 15. PMID 22569295
    2. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. Nguyen BD, et al. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12732728, Free PMC Article
    3. Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. Visconti R, et al. Nat Commun, 2012 Jun 12. PMID 22692537, Free PMC Article
    4. Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Abbott KL, et al. Biochemistry, 2005 Mar 1. PMID 15723517
    5. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, et al. Chem Rev, 2013 Nov 13. PMID 23837720

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that FCP1 plays an important role in endothelin-1-induced cardiac hypertrophy via controlling phosphorylation level of the RNAPII CTD.
      Title: Endothelin-1-induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymerase II.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TFIIF-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Tat protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth involved in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II subunit A C-terminal domain phosphatase
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
    NP_001401324.1
    XP_006255005.1
    XP_006255006.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414395.1 → NP_001401324.1  RNA polymerase II subunit A C-terminal domain phosphatase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      Related
      ENSRNOP00000071476.1, ENSRNOT00000089122.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      76129243..76193404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254943.5 → XP_006255005.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0J7, A0A8I6G995
      Related
      ENSRNOP00000083609.1
      Conserved Domains (4) summary
      TIGR02250
      Location:234 → 380
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd06850
      Location:78 → 168
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd00027
      Location:707 → 776
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam09309
      Location:776 → 867
      FCP1_C; FCP1, C-terminal

    2. XM_006254944.5 → XP_006255006.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0J7
      Conserved Domains (4) summary
      TIGR02250
      Location:234 → 380
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd06850
      Location:78 → 168
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd00027
      Location:707 → 776
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam09309
      Location:776 → 866
      FCP1_C; FCP1, C-terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106131.1: Suppressed sequence

      Description
      NM_001106131.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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