Cndp1 carnosine dipeptidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cndp1provided by RGD
Official Full Name: carnosine dipeptidase 1provided by RGD
Primary source: RGD:1359493
See related: Ensembl:ENSRNOG00000027739 AllianceGenome:RGD:1359493
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dipeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of cellular protein metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 74.0), Uterus (RPKM 31.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (80254499..80305845, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (77984886..78030837, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (81466717..81512841, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-Ala-His dipeptidase

Names: CNDP dipeptidase 1; carnosine dipeptidase 1 (metallopeptidase M20 family)

NP_001007688.1

EC 3.4.13.20

XP_008770357.1

EC 3.4.13.20

XP_038952698.1

EC 3.4.13.20

XP_063133361.1

EC 3.4.13.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007687.2 → NP_001007688.1 beta-Ala-His dipeptidase

See identical proteins and their annotated locations for NP_001007688.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q66HG3

Related

ENSRNOP00000034652.3, ENSRNOT00000034970.6

Conserved Domains (2) summary

PRK08201
Location:16 → 481

PRK08201; hypothetical protein; Provisional

cd05676
Location:13 → 481

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

80254499..80305845 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277291.1 → XP_063133361.1 beta-Ala-His dipeptidase isoform X2
XM_039096770.2 → XP_038952698.1 beta-Ala-His dipeptidase isoform X3

Conserved Domains (1) summary

cd05676
Location:13 → 426

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
XM_008772135.4 → XP_008770357.1 beta-Ala-His dipeptidase isoform X1

See identical proteins and their annotated locations for XP_008770357.1

UniProtKB/Swiss-Prot

Q66HG3

Conserved Domains (2) summary

PRK08201
Location:16 → 481

PRK08201; hypothetical protein; Provisional

cd05676
Location:13 → 481

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase