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    Erp27 endoplasmic reticulum protein 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297698, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Erp27provided by RGD
    Official Full Name
    endoplasmic reticulum protein 27provided by RGD
    Primary source
    RGD:1565381
    See related
    Ensembl:ENSRNOG00000005787 AllianceGenome:RGD:1565381
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565381
    Summary
    Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be active in endoplasmic reticulum. Orthologous to human ERP27 (endoplasmic reticulum protein 27). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 108.5), Liver (RPKM 33.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Erp27 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171535845..171552848, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169804656..169821660, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170893946..170912629, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 4 Neighboring gene matrix Gla protein Neighboring gene Rho GDP dissociation inhibitor beta Neighboring gene uncharacterized LOC134486856

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum resident protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106625.1 → NP_001100095.1  endoplasmic reticulum resident protein 27 precursor

      See identical proteins and their annotated locations for NP_001100095.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6IMJ4, D4A9L9
      Related
      ENSRNOP00000052551.2, ENSRNOT00000055691.3
      Conserved Domains (3) summary
      cd02981
      Location:43 → 139
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:156 → 253
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      pfam13848
      Location:64 → 250
      Thioredoxin_6; Thioredoxin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      171535845..171552848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107460.2 → XP_038963388.1  endoplasmic reticulum resident protein 27 isoform X1

      Conserved Domains (1) summary
      pfam13848
      Location:1 → 174
      Thioredoxin_6; Thioredoxin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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