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    Fubp3 far upstream element binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362106, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fubp3provided by RGD
    Official Full Name
    far upstream element binding protein 3provided by RGD
    Primary source
    RGD:1307004
    See related
    Ensembl:ENSRNOG00000009139 AllianceGenome:RGD:1307004
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Marta2
    Summary
    Predicted to enable mRNA binding activity and single-stranded DNA binding activity. Predicted to be involved in positive regulation of gene expression; positive regulation of transcription, DNA-templated; and transcription, DNA-templated. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Orthologous to human FUBP3 (far upstream element binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 126.1), Lung (RPKM 76.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35253216..35302282)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14855527..14904540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (10220712..10269757, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene hemicentin 2 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene argininosuccinate synthase 1 Neighboring gene PR/SET domain 12 Neighboring gene exosome component 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein engineering of a novel constitutively active hormone-receptor complex. Wu C, et al. J Biol Chem, 1996 Dec 6. PMID 8940183
    2. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. Davis-Smyth T, et al. J Biol Chem, 1996 Dec 6. PMID 8940189
    3. The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. Weber A, et al. BMC Cancer, 2008 Dec 16. PMID 19087307, Free PMC Article
    4. The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons. Zivraj KH, et al. J Neurochem, 2013 Mar. PMID 23121659
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in neurons MARTA2 appears to represent a key trans-acting factor involved in dendritic targeting of MAP2 mRNAs.
      Title: The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125009

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    far upstream element-binding protein 3
    Names
    MAP2 RNA trans-acting protein 2
    far upstream element (FUSE) binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039337.1 → NP_001034426.1  far upstream element-binding protein 3

      See identical proteins and their annotated locations for NP_001034426.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ144645
      UniProtKB/TrEMBL
      A0A8I6G4A0, Q2QC85
      Related
      ENSRNOP00000021871.5, ENSRNOT00000021871.8
      Conserved Domains (2) summary
      smart00322
      Location:161 → 232
      KH; K homology RNA-binding domain
      cd00105
      Location:79 → 141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      35253216..35302282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233924.5 → XP_006233986.1  far upstream element-binding protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ACQ5, A0A8I6ATS5
      Related
      ENSRNOP00000096689.1
      Conserved Domains (2) summary
      smart00322
      Location:161 → 232
      KH; K homology RNA-binding domain
      cd00105
      Location:79 → 141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

    2. XM_063284068.1 → XP_063140138.1  far upstream element-binding protein 3 isoform X5

    3. XM_063284067.1 → XP_063140137.1  far upstream element-binding protein 3 isoform X4

    4. XM_039105375.2 → XP_038961303.1  far upstream element-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G4A0
      Conserved Domains (4) summary
      cd22480
      Location:77 → 147
      KH-I_FUBP3_rpt1; first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
      cd22483
      Location:158 → 240
      KH-I_FUBP3_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
      cd22486
      Location:251 → 320
      KH-I_FUBP3_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
      cd22489
      Location:355 → 423
      KH-I_FUBP3_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins

    5. XM_063284066.1 → XP_063140136.1  far upstream element-binding protein 3 isoform X3

      UniProtKB/TrEMBL
      A6JU26, G3V829

    6. XM_006233921.5 → XP_006233983.1  far upstream element-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006233983.1

      UniProtKB/TrEMBL
      A0A8I6G4A0
      Conserved Domains (2) summary
      smart00322
      Location:161 → 232
      KH; K homology RNA-binding domain
      cd00105
      Location:79 → 141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

    7. XM_006233922.5 → XP_006233984.1  far upstream element-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006233984.1

      UniProtKB/TrEMBL
      A0A8I6G4A0
      Related
      ENSRNOP00000078964.1
      Conserved Domains (2) summary
      smart00322
      Location:161 → 232
      KH; K homology RNA-binding domain
      cd00105
      Location:79 → 141
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

    8. XM_039105376.2 → XP_038961304.1  far upstream element-binding protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6G4A0
      Conserved Domains (4) summary
      cd22483
      Location:72 → 154
      KH-I_FUBP3_rpt2; second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
      cd22486
      Location:165 → 234
      KH-I_FUBP3_rpt3; third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
      cd22489
      Location:269 → 337
      KH-I_FUBP3_rpt4; fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
      cl00098
      Location:1 → 61
      KH-I; K homology (KH) RNA-binding domain, type I

    RNA

    1. XR_010064654.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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