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    Cenpq centromere protein Q [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363198, updated on 13-Apr-2024

    Summary

    Official Symbol
    Cenpqprovided by RGD
    Official Full Name
    centromere protein Qprovided by RGD
    Primary source
    RGD:1359451
    See related
    Ensembl:ENSRNOG00000056226 AllianceGenome:RGD:1359451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in metaphase plate congression and positive regulation of protein localization to kinetochore. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of Mis6-Sim4 complex. Predicted to be active in nucleus. Orthologous to human CENPQ (centromere protein Q). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 65.0), Thymus (RPKM 45.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cenpq in Genome Data Viewer
    Location:
    9q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (27454339..27469371)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (19957122..19972807)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (23352271..23368774)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094642 Neighboring gene methylmalonyl-CoA mutase Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene glycine-N-acyltransferase-like 3 Neighboring gene similar to human chromosome 6 open reading frame 141

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in metaphase chromosome alignment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of inner kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    centromere protein Q
    Names
    CENP-Q

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014215.2NP_001014237.1  centromere protein Q isoform 2

      See identical proteins and their annotated locations for NP_001014237.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q66H02
      UniProtKB/TrEMBL
      A0A8I5ZZW1
      Related
      ENSRNOP00000072803.2, ENSRNOT00000081459.2
      Conserved Domains (1) summary
      pfam13094
      Location:119268
      CENP-Q; a CENPA-CAD centromere complex subunit
    2. NM_001419500.1NP_001406429.1  centromere protein Q isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Related
      ENSRNOP00000084774.1, ENSRNOT00000104636.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      27454339..27469371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)