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    PCNX4 pecanex 4 [ Homo sapiens (human) ]

    Gene ID: 64430, updated on 7-Apr-2024

    Summary

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    Official Symbol
    PCNX4provided by HGNC
    Official Full Name
    pecanex 4provided by HGNC
    Primary source
    HGNC:HGNC:20349
    See related
    Ensembl:ENSG00000126773 AllianceGenome:HGNC:20349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBP2; PCNXL4; C14orf135
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 4.7), endometrium (RPKM 4.5) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    14q23.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60091911..60148221)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54297871..54354503)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60558629..60614939)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene leucine rich repeat containing 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene PCNX4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60558835-60559468 Neighboring gene Sharpr-MPRA regulatory region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5808 Neighboring gene dehydrogenase/reductase 7 Neighboring gene short coiled-coil protein pseudogene 1 Neighboring gene proteasome subunit alpha 3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system. Huang YP, et al. World J Gastroenterol, 2005 Sep 28. PMID 16237761, Free PMC Article
    2. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Andreev DE, et al. Elife, 2015 Jan 26. PMID 25621764, Free PMC Article
    3. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677
    4. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
    5. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Lambert JP, et al. Mol Cell, 2019 Feb 7. PMID 30554943, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12799, FLJ38170

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pecanex-like protein 4
    Names
    HCV F protein-binding protein 2
    HCV F-interacting protein
    hepatitis C virus F protein-binding protein 2
    pecanex homolog 4
    pecanex homolog protein 4
    pecanex-like 4
    pecanex-like protein C14orf135

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330177.2 → NP_001317106.1  pecanex-like protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA651916, AL157911, AL163853
      Consensus CDS
      CCDS81809.1
      UniProtKB/Swiss-Prot
      A8MXM2, Q63HM2, Q9BQG8, Q9H9F2
      Related
      ENSP00000384801.1, ENST00000406854.6

    2. NM_022495.5 → NP_071940.4  pecanex-like protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA651916, AK095489, AL157911, BC033843
      Consensus CDS
      CCDS32091.2
      UniProtKB/TrEMBL
      B5MC47, B6ZDM2
      Related
      ENSP00000317396.4, ENST00000317623.8
      Conserved Domains (1) summary
      pfam05041
      Location:831 → 930
      Pecanex_C; Pecanex protein (C-terminus)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      60091911..60148221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431699.1 → XP_047287655.1  pecanex-like protein 4 isoform X1

    2. XM_047431700.1 → XP_047287656.1  pecanex-like protein 4 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      54297871..54354503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376606.1 → XP_054232581.1  pecanex-like protein 4 isoform X1

    2. XM_054376607.1 → XP_054232582.1  pecanex-like protein 4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63HM2.4 GenPept UniProtKB/Swiss-Prot:Q63HM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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