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    Car11 carbonic anhydrase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308588, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Car11provided by RGD
    Official Full Name
    carbonic anhydrase 11provided by RGD
    Primary source
    RGD:735155
    See related
    Ensembl:ENSRNOG00000021017 AllianceGenome:RGD:735155
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca11; CAR-XI
    Summary
    Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in basolateral plasma membrane. Orthologous to human CA11 (carbonic anhydrase 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 177.4), Uterus (RPKM 52.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105306347..105311651)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96169900..96175191)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101682009..101687358)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 2 Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene sphingosine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. Verlander JW, et al. Am J Physiol Renal Physiol, 2003 Feb. PMID 12388412
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93050

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase-related protein 11
    Names
    carbonic anhydrase-related XI protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175708.3 → NP_783639.1  carbonic anhydrase-related protein 11 precursor

      See identical proteins and their annotated locations for NP_783639.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086972
      UniProtKB/TrEMBL
      F7FEL0, Q811X3
      Related
      ENSRNOP00000028540.3, ENSRNOT00000028540.5
      Conserved Domains (1) summary
      cd03121
      Location:48 → 304
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105306347..105311651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262113.1 → XP_063118183.1  carbonic anhydrase-related protein 11 isoform X2

    2. XM_063262112.1 → XP_063118182.1  carbonic anhydrase-related protein 11 isoform X1

    3. XM_017589148.3 → XP_017444637.1  carbonic anhydrase-related protein 11 isoform X3

    4. XM_017589149.3 → XP_017444638.1  carbonic anhydrase-related protein 11 isoform X4

    5. XM_063262118.1 → XP_063118188.1  carbonic anhydrase-related protein 11 isoform X5

    6. XM_063262120.1 → XP_063118190.1  carbonic anhydrase-related protein 11 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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