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    Cyth2 cytohesin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116692, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cyth2provided by RGD
    Official Full Name
    cytohesin 2provided by RGD
    Primary source
    RGD:620398
    See related
    Ensembl:ENSRNOG00000021051 AllianceGenome:RGD:620398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arno; CLM2; Sec7; Pscd2; Sec7B
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and inositol 1,4,5 trisphosphate binding activity. Involved in negative regulation of dendrite development. Located in ruffle. Is extrinsic component of postsynaptic specialization membrane. Orthologous to human CYTH2 (cytohesin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 174.9), Lung (RPKM 159.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105419631..105427542, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96283182..96291094, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101796349..101803407, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 2B member 1 Neighboring gene uncharacterized LOC134483107 Neighboring gene lemur tyrosine kinase 3 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene glutamate-rich WD repeat containing 1 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets. Jayaram B, et al. Biochem Pharmacol, 2011 Apr 15. PMID 21276423, Free PMC Article
    2. A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons. Hernández-Deviez D, et al. Traffic, 2007 Dec. PMID 17897316
    3. Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. Cronin TC, et al. EMBO J, 2004 Oct 1. PMID 15359279, Free PMC Article
    4. Regulation of dendritic development by the ARF exchange factor ARNO. Hernández-Deviez DJ, et al. Nat Neurosci, 2002 Jul. PMID 12032543
    5. Localization of mRNAs for subfamily of guanine nucleotide-exchange proteins (GEP) for ARFs (ADP-ribosylation factors) in the brain of developing and mature rats under normal and postaxotomy conditions. Suzuki I, et al. Brain Res Mol Brain Res, 2002 Jan 31. PMID 11834294

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
      Title: The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.
    2. endotubin labels a distinct endosomal structure in neurons; and ARNO and ARF6 mediate neurite extension through the regulation of this compartment
      Title: A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons.
    3. cytohesin 2 binds to IPCEF1, which modifies its activity
      Title: Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extrinsic component of postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytohesin-2
    Names
    ARF nucleotide binding site opener
    PH, SEC7 and coiled-coil domain-containing protein 2
    SEC7 homolog B
    pleckstrin homology, Sec7 and coiled-coil domains 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395066.1 → NP_001381995.1  cytohesin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LSU6
      Related
      ENSRNOP00000028588.6, ENSRNOT00000028588.7
      Conserved Domains (2) summary
      cd01252
      Location:258 → 377
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:61 → 243
      Sec7; Sec7 domain

    2. NM_053911.3 → NP_446363.1  cytohesin-2 isoform 1

      See identical proteins and their annotated locations for NP_446363.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O89099, P63035, P97695
      UniProtKB/TrEMBL
      F1LSU6
      Conserved Domains (2) summary
      cd01252
      Location:258 → 378
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:61 → 243
      Sec7; Sec7 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105419631..105427542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63035.1 GenPept UniProtKB/Swiss-Prot:P63035

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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