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    Sp110 SP110 nuclear body protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301570, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Sp110provided by RGD
    Official Full Name
    SP110 nuclear body proteinprovided by RGD
    Primary source
    RGD:1310173
    See related
    Ensembl:ENSRNOG00000033747 AllianceGenome:RGD:1310173
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of apoptotic process and response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatic venoocclusive disease with immunodeficiency and tuberculosis. Orthologous to human SP110 (SP110 nuclear body protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 350.6), Thymus (RPKM 325.7) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sp110 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93648574..93673476, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (86200503..86225355, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (92593909..92618867, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 16, member 14 Neighboring gene uncharacterized LOC120094727 Neighboring gene uncharacterized LOC134480599 Neighboring gene component of Sp100-rs Neighboring gene SP140 nuclear body protein Neighboring gene SP100 nuclear antigen Neighboring gene RIKEN cDNA A630001G21 gene like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ipr1 gene mediates innate immunity to tuberculosis. Pan H, et al. Nature, 2005 Apr 7. PMID 15815631, Free PMC Article
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124651

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sp110 nuclear body protein
    Names
    intracellular pathogen resistance protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034137.1 → NP_001029309.1  sp110 nuclear body protein

      See identical proteins and their annotated locations for NP_001029309.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105751
      UniProtKB/Swiss-Prot
      Q3KRF1
      UniProtKB/TrEMBL
      R9PXZ9
      Related
      ENSRNOP00000053828.5, ENSRNOT00000056995.5
      Conserved Domains (2) summary
      pfam01342
      Location:390 → 465
      SAND; SAND domain
      pfam03172
      Location:8 → 106
      HSR; HSR domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      93648574..93673476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267020.1 → XP_063123090.1  sp110 nuclear body protein isoform X1

      UniProtKB/Swiss-Prot
      Q3KRF1
      UniProtKB/TrEMBL
      R9PXZ9

    2. XM_039083401.2 → XP_038939329.1  sp110 nuclear body protein isoform X1

      UniProtKB/Swiss-Prot
      Q3KRF1
      UniProtKB/TrEMBL
      R9PXZ9
      Conserved Domains (2) summary
      pfam01342
      Location:390 → 465
      SAND; SAND domain
      pfam03172
      Location:8 → 106
      HSR; HSR domain

    3. XM_039083402.2 → XP_038939330.1  sp110 nuclear body protein isoform X1

      UniProtKB/Swiss-Prot
      Q3KRF1
      UniProtKB/TrEMBL
      R9PXZ9
      Conserved Domains (2) summary
      pfam01342
      Location:390 → 465
      SAND; SAND domain
      pfam03172
      Location:8 → 106
      HSR; HSR domain

    4. XM_039083404.2 → XP_038939332.1  sp110 nuclear body protein isoform X3

      UniProtKB/TrEMBL
      R9PXZ9
      Conserved Domains (2) summary
      pfam01342
      Location:336 → 411
      SAND; SAND domain
      pfam03172
      Location:8 → 106
      HSR; HSR domain

    5. XM_039083403.2 → XP_038939331.1  sp110 nuclear body protein isoform X2

      UniProtKB/TrEMBL
      R9PXZ9
      Conserved Domains (2) summary
      pfam01342
      Location:362 → 437
      SAND; SAND domain
      pfam03172
      Location:8 → 106
      HSR; HSR domain

    6. XM_063267021.1 → XP_063123091.1  sp110 nuclear body protein isoform X5

    7. XM_039083405.2 → XP_038939333.1  sp110 nuclear body protein isoform X4

      Conserved Domains (1) summary
      pfam01342
      Location:180 → 255
      SAND; SAND domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KRF1.1 GenPept UniProtKB/Swiss-Prot:Q3KRF1

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