ATAD2 ATPase family AAA domain containing 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ATAD2provided by HGNC
Official Full Name: ATPase family AAA domain containing 2provided by HGNC
Primary source: HGNC:HGNC:30123
See related: Ensembl:ENSG00000156802 MIM:611941; AllianceGenome:HGNC:30123
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANCCA; CT137; PRO2000
Summary: A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.13

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (123319850..123416350, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (124450947..124547457, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (124332090..124408687, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
Title: Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.
MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
Title: MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.
Title: ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration.
Tumor-Promoting ATAD2 and Its Preclinical Challenges.
Title: Tumor-Promoting ATAD2 and Its Preclinical Challenges.
Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
Title: Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA + ATPase domain and bromodomain.
Effect of chronic intermittent hypoxia-induced HIF-1alpha/ATAD2 expression on lung cancer stemness.
Title: Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness.
ATAD2 controls chromatin-bound HIRA turnover.
Title: ATAD2 controls chromatin-bound HIRA turnover.
ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
Title: ATAD2 drives colorectal cancer progression by regulating TRIM25 expression via a positive feedback loop with E2F transcriptional factors.
ATAD2 interacts with C/EBPbeta to promote esophageal squamous cell carcinoma metastasis via TGF-beta1/Smad3 signaling.
Title: ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain.
Title: Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH77936 (e-PCR)
- UniSTS:45896

RH80934 (e-PCR)
- UniSTS:84048

D8S1689 (e-PCR)
- UniSTS:154250

RH80997 (e-PCR)
- UniSTS:84107

WI-20906 (e-PCR)
- UniSTS:4329

RH66014 (e-PCR)
- UniSTS:60157

Clone Names

MGC5254, MGC29843, MGC131938, MGC142216, DKFZp667N1320

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATPase family AAA domain-containing protein 2

Names: AAA nuclear coregulator cancer-associated protein

NP_054828.2

EC 3.6.1.3

XP_011515296.1

EC 3.6.1.3

XP_011515297.1

EC 3.6.1.3

XP_011515298.1

EC 3.6.1.3

XP_047277678.1

EC 3.6.1.3

XP_047277679.1

EC 3.6.1.3

XP_047277680.1

EC 3.6.1.3

XP_047277681.1

EC 3.6.1.3

XP_054216337.1

EC 3.6.1.3

XP_054216338.1

EC 3.6.1.3

XP_054216339.1

EC 3.6.1.3

XP_054216340.1

EC 3.6.1.3

XP_054216341.1

EC 3.6.1.3

XP_054216342.1

EC 3.6.1.3

XP_054216343.1

EC 3.6.1.3

XP_054216344.1

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014109.4 → NP_054828.2 ATPase family AAA domain-containing protein 2

See identical proteins and their annotated locations for NP_054828.2

Status: REVIEWED

Source sequence(s)

BC113656, BP314109, CA441499, CB159561

Consensus CDS

CCDS6343.1

UniProtKB/Swiss-Prot

Q14CR1, Q658P2, Q68CQ0, Q6PJV6, Q6PL18, Q8N890, Q9UHS5

Related

ENSP00000287394.5, ENST00000287394.10

Conserved Domains (4) summary

cd05528
Location:987 → 1097

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:459 → 600

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:915 → 1153

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:464 → 598

AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

123319850..123416350 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421723.1 → XP_047277679.1 ATPase family AAA domain-containing protein 2 isoform X2
XM_047421722.1 → XP_047277678.1 ATPase family AAA domain-containing protein 2 isoform X2
XM_011516994.4 → XP_011515296.1 ATPase family AAA domain-containing protein 2 isoform X1

Conserved Domains (4) summary

cd05528
Location:987 → 1097

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

smart00382
Location:459 → 600

AAA; ATPases associated with a variety of cellular activities

COG5076
Location:915 → 1160

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00004
Location:464 → 598

AAA; ATPase family associated with various cellular activities (AAA)
XM_011516996.4 → XP_011515298.1 ATPase family AAA domain-containing protein 2 isoform X4

UniProtKB/TrEMBL

A0A0B4J211

Related

ENSP00000429213.1, ENST00000521903.5

Conserved Domains (2) summary

cd05528
Location:446 → 556

Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...

cl21455
Location:17 → 57

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_047421724.1 → XP_047277680.1 ATPase family AAA domain-containing protein 2 isoform X5
XM_011516995.4 → XP_011515297.1 ATPase family AAA domain-containing protein 2 isoform X3

Related

ENST00000521496.5

Conserved Domains (2) summary

smart00382
Location:459 → 600

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:464 → 598

AAA; ATPase family associated with various cellular activities (AAA)
XM_047421725.1 → XP_047277681.1 ATPase family AAA domain-containing protein 2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

124450947..124547457 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054360364.1 → XP_054216339.1 ATPase family AAA domain-containing protein 2 isoform X2
XM_054360363.1 → XP_054216338.1 ATPase family AAA domain-containing protein 2 isoform X2
XM_054360362.1 → XP_054216337.1 ATPase family AAA domain-containing protein 2 isoform X1
XM_054360365.1 → XP_054216340.1 ATPase family AAA domain-containing protein 2 isoform X2
XM_054360367.1 → XP_054216342.1 ATPase family AAA domain-containing protein 2 isoform X4
XM_054360368.1 → XP_054216343.1 ATPase family AAA domain-containing protein 2 isoform X5
XM_054360366.1 → XP_054216341.1 ATPase family AAA domain-containing protein 2 isoform X3
XM_054360369.1 → XP_054216344.1 ATPase family AAA domain-containing protein 2 isoform X6