Frmd4b FERM domain containing 4B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Frmd4bprovided by RGD
Official Full Name: FERM domain containing 4Bprovided by RGD
Primary source: RGD:620172
See related: Ensembl:ENSRNOG00000007764 AllianceGenome:RGD:620172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Grsp1; Nitzin
Summary: Predicted to act upstream of or within establishment of epithelial cell polarity. Predicted to be located in cytoplasm and ruffle. Predicted to be active in adherens junction and bicellular tight junction. Orthologous to human FRMD4B (FERM domain containing 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 102.5), Spleen (RPKM 71.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (131452361..131778734, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (129895401..130222070, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (129658137..129984735, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D4Rat92 (e-PCR), detects polymorphism
- UniSTS:227840

RH138356 (e-PCR)
- UniSTS:220443

D4Rat80 (e-PCR)
- UniSTS:118872

D4Got96 (e-PCR)
- UniSTS:115554

BF399462 (e-PCR)
- UniSTS:247692

RH143872 (e-PCR)
- UniSTS:233118

RH142646 (e-PCR)
- UniSTS:231893

D4Rat88 (e-PCR), detects polymorphism
- UniSTS:227838

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FERM domain-containing protein 4B

Names: GRP1 binding protein GRSP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427301.2 → NP_001414230.1 FERM domain-containing protein 4B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I5ZRG3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

131452361..131778734 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285583.1 → XP_063141653.1 FERM domain-containing protein 4B isoform X4
XM_063285579.1 → XP_063141649.1 FERM domain-containing protein 4B isoform X1
XM_063285582.1 → XP_063141652.1 FERM domain-containing protein 4B isoform X3

UniProtKB/TrEMBL

A0A8I5ZUV5
XM_063285580.1 → XP_063141650.1 FERM domain-containing protein 4B isoform X2

UniProtKB/TrEMBL

F1LZB7
XM_063285584.1 → XP_063141654.1 FERM domain-containing protein 4B isoform X5
XM_063285585.1 → XP_063141655.1 FERM domain-containing protein 4B isoform X5