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    Pnpla3 patatin-like phospholipase domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362972, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pnpla3provided by RGD
    Official Full Name
    patatin-like phospholipase domain containing 3provided by RGD
    Primary source
    RGD:1595843
    See related
    Ensembl:ENSRNOG00000022268 AllianceGenome:RGD:1595843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adpn
    Summary
    Predicted to enable several functions, including acylglycerol O-acyltransferase activity; lipase activity; and long-chain fatty acyl-CoA binding activity. Involved in cellular response to organonitrogen compound; response to sucrose; and white fat cell differentiation. Predicted to be active in cytoplasm; lipid droplet; and membrane. Biomarker of hypothyroidism and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 270.1), Adrenal (RPKM 106.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117173485..117194065)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115293538..115314077)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (125034760..125056165)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 4A, member 1 Neighboring gene patatin-like phospholipase domain containing 5 Neighboring gene uncharacterized LOC134479759 Neighboring gene SAMM50 sorting and assembly machinery component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cold exposure down-regulates adiponutrin/PNPLA3 mRNA expression and affects its nutritional regulation in adipose tissues of lean and obese Zucker rats. Oliver P, et al. Br J Nutr, 2012 May. PMID 21914237
    2. Regulation of adiponutrin expression by feeding conditions in rats is altered in the obese state. Caimari A, et al. Obesity (Silver Spring), 2007 Mar. PMID 17372308
    3. Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet. Polson DA, et al. Biochem Biophys Res Commun, 2003 Feb 7. PMID 12565853
    4. Inulin may prevent steatosis by suppressing cannabinoid receptor-1 and patatin-like phospholipase-3 expression in liver. Alptekin İM, et al. Nutrition, 2022 Nov-Dec. PMID 35908495
    5. PNPLA3 gene polymorphism in Brazilian patients with type 2 diabetes: A prognostic marker beyond liver disease? Machado CM, et al. Nutr Metab Cardiovasc Dis, 2019 Sep. PMID 31377187

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inulin may prevent steatosis by suppressing cannabinoid receptor-1 and patatin-like phospholipase-3 expression in liver.
      Title: Inulin may prevent steatosis by suppressing cannabinoid receptor-1 and patatin-like phospholipase-3 expression in liver.
    2. Histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol drinking.
      Title: Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation.
    3. adiponutrin/PNPLA3 has a role in adipogenesis, as shown by its inhibition by cold in adipose tissue
      Title: Cold exposure down-regulates adiponutrin/PNPLA3 mRNA expression and affects its nutritional regulation in adipose tissues of lean and obese Zucker rats.
    4. PNPLA3 mRNA expression is upregulated by tri-iodothyronine in adipocytes in vitro, in humans and rats, and in vivo in rat white adipose tissue.
      Title: Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes.
    5. Adiponutrin expression is highly regulated by feeding conditions in the different adipose tissue depots, but this regulation is impaired in obese rats.
      Title: Regulation of adiponutrin expression by feeding conditions in rats is altered in the obese state.
    6. Data suggest that adiponutrin could be involved in overall energy homeostasis, as is leptin.
      Title: Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diolein transacylation activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mono-olein transacylation activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables triglyceride lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triglyceride lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glycerophospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in triglyceride acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in white fat cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-acylglycerol-3-phosphate O-acyltransferase PNPLA3
    Names
    adiponutrin
    patatin-like phospholipase domain-containing protein 3
    NP_001269253.1
    XP_063120012.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282324.1 → NP_001269253.1  1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

      Status: VALIDATED

      Source sequence(s)
      BC161881, FM042237, FM043479
      UniProtKB/TrEMBL
      A6HTB3, D3Z9J9
      Related
      ENSRNOP00000015767.5, ENSRNOT00000015767.8
      Conserved Domains (1) summary
      cl11396
      Location:8 → 259
      Patatin_and_cPLA2; Patatins and Phospholipases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      117173485..117194065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263942.1 → XP_063120012.1  1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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