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    KLK10 kallikrein related peptidase 10 [ Homo sapiens (human) ]

    Gene ID: 5655, updated on 3-Apr-2024

    Summary

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    Official Symbol
    KLK10provided by HGNC
    Official Full Name
    kallikrein related peptidase 10provided by HGNC
    Primary source
    HGNC:HGNC:6358
    See related
    Ensembl:ENSG00000129451 MIM:602673; AllianceGenome:HGNC:6358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NES1; PRSSL1
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in esophagus (RPKM 28.7), skin (RPKM 8.9) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51012739..51020097, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54101211..54108579, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51515995..51523353, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51509835-51510334 Neighboring gene kallikrein related peptidase 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51512731-51513231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51528951-51529509 Neighboring gene kallikrein related peptidase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51529510-51530067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51530627-51531183 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51533216-51533447 Neighboring gene kallikrein related peptidase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10. Zhao J, et al. Pathol Res Pract, 2022 Aug. PMID 35691099
    2. Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia. Ahmad SM, et al. PeerJ, 2022. PMID 35669967, Free PMC Article
    3. MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10. Liu T, et al. Histol Histopathol, 2022 Mar. PMID 34935123
    4. The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility. Güleç Yılmaz S, et al. Urol J, 2021 May 26. PMID 34089177
    5. Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway. Wei H, et al. Neoplasma, 2020 Jul. PMID 32386481

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
      Title: KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
    2. Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer.
      Title: Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer.
    3. Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia.
      Title: Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia.
    4. miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10.
      Title: miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10.
    5. MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.
      Title: MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.
    6. The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.
      Title: The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.
    7. Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
      Title: Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
    8. The data suggest that via inhibition of BCL-2 expression, overexpressed NES1 might enhance the effect of radiation therapy of (131)I uptake in hNIS overexpressed PC3 cells.
      Title: NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition.
    9. findings show that KLK10 promotes trastuzumab resistance, at least in part, through the PI3K/AKT signaling pathway, suggesting that KLK10 is a potentially target to overcome trastuzumab resistance, and the combination might overcome trastuzumab resistance in KLK10-overexpressed gastric cancer patients.
      Title: NES1/KLK10 promotes trastuzumab resistance via activation of PI3K/AKT signaling pathway in gastric cancer.
    10. MiR-199b-5p promotes cell proliferation, migration and suppresses apoptosis in cervical cancer cells. KLK10 is a direct target of miR-199b-5p. MiR-199b-5p expression is increased and positively correlated with KI-67 in human cervical cancer tissues and cell lines.
      Title: MiR-199b-5p promotes tumor growth and metastasis in cervical cancer by down-regulating KLK10.
    Submit: New GeneRIF Correction See all GeneRIFs (60)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kallikrein-10
    Names
    breast normal epithelial cell associated serine protease
    kallikrein 10 protein 1
    kallikrein 10 protein 12
    kallikrein 10 protein 13
    kallikrein 10 protein 2
    kallikrein 10 protein 3
    kallikrein 10 protein 4
    kallikrein 10 protein 5
    kallikrein 10 protein 7
    kallikrein 10 protein 8
    kallikrein 10 protein 9
    normal epithelial cell-specific 1
    protease serine-like 1
    NP_001070968.1
    NP_002767.2
    NP_665895.1
    XP_005259118.1
    XP_005259119.1
    XP_006723350.1
    XP_006723352.1
    XP_016882482.1
    XP_047295058.1
    XP_054177453.1
    XP_054177454.1
    XP_054177455.1
    XP_054177456.1
    XP_054177457.1
    XP_054177458.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077500.2 → NP_001070968.1  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_001070968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AY561635, BM830577, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Related
      ENSP00000375681.1, ENST00000391805.5
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_002776.5 → NP_002767.2  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_002767.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AY561635, BC002710, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Related
      ENSP00000311746.2, ENST00000309958.7
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_145888.3 → NP_665895.1  kallikrein-10 preproprotein

      See identical proteins and their annotated locations for NP_665895.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.
      Source sequence(s)
      AC011473, AF024605, AY561635, BU685208
      Consensus CDS
      CCDS12817.1
      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Related
      ENSP00000351640.2, ENST00000358789.8
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51012739..51020097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439102.1 → XP_047295058.1  kallikrein-10 isoform X1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

    2. XM_006723289.4 → XP_006723352.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_006723352.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_005259061.4 → XP_005259118.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_005259118.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_006723287.5 → XP_006723350.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_006723350.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    5. XM_005259062.4 → XP_005259119.1  kallikrein-10 isoform X1

      See identical proteins and their annotated locations for XP_005259119.1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    6. XM_017026993.3 → XP_016882482.1  kallikrein-10 isoform X1

      UniProtKB/Swiss-Prot
      A6NC12, O43240, Q53YL3, Q99920, Q9GZW9
      UniProtKB/TrEMBL
      W8GRM7, W8GWD1
      Conserved Domains (2) summary
      smart00020
      Location:49 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:49 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54101211..54108579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321483.1 → XP_054177458.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6

    2. XM_054321482.1 → XP_054177457.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6

    3. XM_054321478.1 → XP_054177453.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6

    4. XM_054321479.1 → XP_054177454.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6

    5. XM_054321481.1 → XP_054177456.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6

    6. XM_054321480.1 → XP_054177455.1  kallikrein-10 isoform X1

      UniProtKB/TrEMBL
      Q6ICR6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43240.3 GenPept UniProtKB/Swiss-Prot:O43240

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