Fabp5 fatty acid binding protein 5, epidermal [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fabp5provided by MGI
Official Full Name: fatty acid binding protein 5, epidermalprovided by MGI
Primary source: MGI:MGI:101790
See related: Ensembl:ENSMUSG00000027533 AllianceGenome:MGI:101790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Klbp; mal1; Fabpe; E-FABP; PA-FABP
Summary: The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]
Expression: Biased expression in liver E18 (RPKM 937.5), liver E14 (RPKM 371.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A1; 3 2.47 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (10077645..10081670)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (10012585..10016610)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome.
Title: High levels of fatty acid-binding protein 5 excessively enhances fatty acid synthesis and proliferation of granulosa cells in polycystic ovary syndrome.
Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis.
Title: Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis.
FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Delta9 tetrahydrocannabinol inhalation in mice.
Title: FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in mice.
Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid-binding protein 5.
Title: Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid-binding protein 5.
Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
Title: Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
FABP5 Deficiency Impaired Macrophage Inflammation by Regulating AMPK/NF-kappaB Signaling Pathway.
Title: FABP5 Deficiency Impaired Macrophage Inflammation by Regulating AMPK/NF-κB Signaling Pathway.
FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism.
Title: FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism.
Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/beta-catenin pathway.
Title: Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway.
Epidermal Fatty AcidBinding Protein Mediates Depilatory-Induced Acute Skin Inflammation.
Title: Epidermal Fatty Acid‒Binding Protein Mediates Depilatory-Induced Acute Skin Inflammation.
Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor.
Title: Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fabp5 (e-PCR), detects polymorphism
- UniSTS:499179

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylcholine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde trans-synaptic signaling by endocannabinoid	EXP Inferred from Experiment more info	PubMed
involved_in retrograde trans-synaptic signaling by endocannabinoid	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde trans-synaptic signaling by endocannabinoid	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fatty acid-binding protein 5; uncharacterized protein LOC16592

Names: epidermal-type fatty acid-binding protein; epithelial fatty acid-binding protein; fatty acid-binding protein, epidermal; keratinocyte lipid-binding protein; psoriasis-associated fatty acid-binding protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001272097.1 → NP_001259026.1 fatty acid-binding protein 5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (by one amino acid; isoform 2), compared to isoform 1.

Source sequence(s)

AC157379

Conserved Domains (1) summary

pfam00061
Location:9 → 111

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_001272098.1 → NP_001259027.1 uncharacterized protein LOC16592 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. Variant 3 lacks a large portion of the central coding region found in variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform lacks the lipocalin domain found in isoform 1.

Source sequence(s)

AC157379, BE987062, W54445

Conserved Domains (1) summary

cl10502
Location:6 → 26

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
NM_010634.3 → NP_034764.1 fatty acid-binding protein 5 isoform 1

See identical proteins and their annotated locations for NP_034764.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC157379, AK011551, BE987062

Consensus CDS

CCDS38388.1

UniProtKB/Swiss-Prot

Q05816

UniProtKB/TrEMBL

Q497I3

Related

ENSMUSP00000029046.9, ENSMUST00000029046.9

Conserved Domains (1) summary

pfam00061
Location:9 → 134

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family