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    Plch1 phospholipase C, eta 1 [ Mus musculus (house mouse) ]

    Gene ID: 269437, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Plch1provided by MGI
    Official Full Name
    phospholipase C, eta 1provided by MGI
    Primary source
    MGI:MGI:2683547
    See related
    Ensembl:ENSMUSG00000036834 AllianceGenome:MGI:2683547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plcl3; PLCeta1; PLC-eta-1
    Summary
    Predicted to enable calcium-dependent phospholipase C activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling. Predicted to act upstream of or within lipid catabolic process and signal transduction. Located in cytosol and membrane. Is expressed in intestine; musculoskeletal system; nervous system; and neural retina. Orthologous to human PLCH1 (phospholipase C eta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 3.5), whole brain E14.5 (RPKM 2.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plch1 in Genome Data Viewer
    Location:
    3 E1; 3 30.08 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63603620..63806929, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63696199..63899503, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34240 Neighboring gene STARR-seq mESC enhancer starr_07833 Neighboring gene small transmembrane regulator of ion transport 1 Neighboring gene STARR-seq mESC enhancer starr_07834 Neighboring gene STARR-seq mESC enhancer starr_07835 Neighboring gene STARR-seq mESC enhancer starr_07836 Neighboring gene STARR-seq mESC enhancer starr_07837 Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene predicted gene, 34379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phospholipase C-η1 is activated by intracellular Ca(2+) mobilization and enhances GPCRs/PLC/Ca(2+) signaling. Kim JK, et al. Cell Signal, 2011 Jun. PMID 21262355
    2. Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice. Dzhura I, et al. J Physiol, 2010 Dec 15. PMID 21041529, Free PMC Article
    3. Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. Stewart AJ, et al. Int J Mol Med, 2005 Jan. PMID 15583837
    4. Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Zhang L, et al. Cell, 2013 Mar 28. PMID 23540699, Free PMC Article
    5. Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Hwang JI, et al. Biochem J, 2005 Jul 1. PMID 15702972, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study concludes that perinuclear PLCepsilon, scaffolded to mAKAP in cardiac myocytes, responds to hypertrophic stimuli to generate diacylglycerol (DAG) from PI4P in the Golgi apparatus, in close proximity to the nuclear envelope, to regulate activation of nuclear PKD and hypertrophic signaling pathways.
      Title: Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.
    2. Phospholipase C-eta was found to be expressed in mouse beta-cells, and knockout of that gene disrupts the action of exendin-4 to facilitate calcium-induced calcium release in the beta-cells of these mice.
      Title: Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.
    3. PLC-eta1 is activated via intracellular calcium mobilization from the endoplasmic reticulum, and therefore amplifies G-protein coupled receptor mediated signaling
      Title: Phospholipase C-η1 is activated by intracellular Ca(2+) mobilization and enhances GPCRs/PLC/Ca(2+) signaling.
    4. The identification of a novel PLC isoform in the brains of human and mouse, named PLC-eta, which contains the conserved pleckstrin homology domain, X and Y domains for catalytic activity and the C2 domain.
      Title: Molecular cloning and characterization of a novel phospholipase C, PLC-eta.
    5. molecular cloning of PLC-eta1 and PLC-eta2.
      Title: Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC57096

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
    Names
    phosphoinositide phospholipase C-eta-1
    phospholipase C-like protein 3
    NP_001171203.1
    NP_001171204.1
    NP_001357913.1
    NP_001357914.1
    NP_899014.2
    XP_006501593.1
    XP_006501594.1
    XP_006501596.1
    XP_006501598.1
    XP_006501599.1
    XP_006501601.1
    XP_006501604.1
    XP_011238433.1
    XP_011238435.1
    XP_011238436.1
    XP_017175082.1
    XP_017175083.1
    XP_017175084.1
    XP_017175085.1
    XP_017175087.1
    XP_017175088.1
    XP_017175089.1
    XP_017175090.1
    XP_030108492.1
    XP_030108493.1
    XP_036019019.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177732.2 → NP_001171203.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3

      See identical proteins and their annotated locations for NP_001171203.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as PLC-eta1a) differs in the 3' UTR and includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. This results in an isoform (3, also known as phospholipase C-eta1a) that has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC116732, AC121285
      Consensus CDS
      CCDS57215.1
      UniProtKB/TrEMBL
      H3BKE1
      Related
      ENSMUSP00000124463.3, ENSMUST00000162269.9
      Conserved Domains (7) summary
      cd00275
      Location:732 → 856
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298 → 702
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:146 → 212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227 → 298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147 → 208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441 → 542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22 → 128
      PH-like; Pleckstrin homology-like domain

    2. NM_001177733.2 → NP_001171204.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 2

      See identical proteins and their annotated locations for NP_001171204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as PLC-eta1b) includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. This results in an isoform (2, also known as phospholipase C-eta1b) that has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC116732, AC121285
      Consensus CDS
      CCDS50918.1
      UniProtKB/TrEMBL
      H3BKE1
      Related
      ENSMUSP00000124632.3, ENSMUST00000159676.9
      Conserved Domains (7) summary
      cd00275
      Location:732 → 856
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298 → 702
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:146 → 212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227 → 298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147 → 208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441 → 542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22 → 128
      PH-like; Pleckstrin homology-like domain

    3. NM_001370984.1 → NP_001357913.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116732, AC121285
      UniProtKB/TrEMBL
      I1E4X4
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    4. NM_001370985.1 → NP_001357914.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116732, AC121285
      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:731 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298 → 701
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:146 → 175
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:146 → 286
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:22 → 128
      PH-like; Pleckstrin homology-like domain

    5. NM_183191.4 → NP_899014.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1

      See identical proteins and their annotated locations for NP_899014.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as PLC-eta1c) encodes the longest isoform (1, also known as phospholipase C-eta1c).
      Source sequence(s)
      AC116732, AC121285
      Consensus CDS
      CCDS38444.2
      UniProtKB/Swiss-Prot
      Q4KWH5, Q4KWH6, Q4KWH7, Q69ZS3, Q7TPQ1, Q8CFQ2
      UniProtKB/TrEMBL
      I1E4X6
      Related
      ENSMUSP00000081122.6, ENSMUST00000084105.12
      Conserved Domains (7) summary
      cd00275
      Location:732 → 856
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:298 → 702
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd00051
      Location:146 → 212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam09279
      Location:227 → 298
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      pfam13499
      Location:147 → 208
      EF-hand_7; EF-hand domain pair
      cl00292
      Location:441 → 542
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
      cl17171
      Location:22 → 128
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      63603620..63806929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252633.2 → XP_030108493.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X10

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:743 → 867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    2. XM_006501541.5 → XP_006501604.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    3. XM_017319596.3 → XP_017175085.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    4. XM_006501536.5 → XP_006501599.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    5. XM_006501533.5 → XP_006501596.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501596.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    6. XM_017319595.3 → XP_017175084.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:690 → 814
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 660
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    7. XM_006501535.5 → XP_006501598.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:743 → 867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    8. XM_006501530.5 → XP_006501593.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501593.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    9. XM_011240131.4 → XP_011238433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_011238433.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    10. XM_017319593.3 → XP_017175082.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    11. XM_006501531.5 → XP_006501594.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501594.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    12. XM_017319594.1 → XP_017175083.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (4) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    13. XM_011240134.3 → XP_011238436.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

      See identical proteins and their annotated locations for XP_011238436.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (2) summary
      cd08632
      Location:115 → 519
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:44 → 659
      PLN02228; Phosphoinositide phospholipase C

    14. XM_011240133.3 → XP_011238435.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

      See identical proteins and their annotated locations for XP_011238435.1

      UniProtKB/TrEMBL
      I1E4X6
      Conserved Domains (2) summary
      cd08632
      Location:115 → 519
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02228
      Location:44 → 659
      PLN02228; Phosphoinositide phospholipase C

    15. XM_017319600.3 → XP_017175089.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X13

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd08632
      Location:310 → 713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      PLN02230
      Location:285 → 853
      PLN02230; phosphoinositide phospholipase C 4
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    16. XM_017319601.3 → XP_017175090.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X14

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    17. XM_017319599.3 → XP_017175088.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X12

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    18. XM_006501538.5 → XP_006501601.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

      UniProtKB/TrEMBL
      H3BKK4, I1E4X4
      Related
      ENSMUSP00000135424.2, ENSMUST00000177143.8
      Conserved Domains (4) summary
      cd00275
      Location:743 → 867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    19. XM_017319598.3 → XP_017175087.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X11

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:744 → 868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 714
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    20. XM_036163126.1 → XP_036019019.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X15

      UniProtKB/TrEMBL
      H3BKE1
      Conserved Domains (5) summary
      cd00275
      Location:743 → 867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd15898
      Location:158 → 187
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:158 → 298
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain

    21. XM_030252632.2 → XP_030108492.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

      UniProtKB/TrEMBL
      I1E4X4
      Conserved Domains (4) summary
      cd00275
      Location:743 → 867
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08632
      Location:310 → 713
      PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
      cd16220
      Location:158 → 298
      EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
      cl17171
      Location:34 → 140
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KWH5.1 GenPept UniProtKB/Swiss-Prot:Q4KWH5

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