Pcsk9 proprotein convertase subtilisin/kexin type 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcsk9provided by RGD
Official Full Name: proprotein convertase subtilisin/kexin type 9provided by RGD
Primary source: RGD:728909
See related: Ensembl:ENSRNOG00000006280 AllianceGenome:RGD:728909
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PC9; Narc1; NARC-1
Summary: Predicted to enable several functions, including lipoprotein particle binding activity; lipoprotein particle receptor binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to insulin stimulus; cholesterol homeostasis; and protein autoprocessing. Located in extracellular space and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 274.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (126440102..126462507, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (121211278..121233688, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (126031368..126053726, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction.
Title: PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction.
High-salt diet induces dyslipidemia through the SREBP2/PCSK9 pathway in dahl salt-sensitive rats.
Title: High-salt diet induces dyslipidemia through the SREBP2/PCSK9 pathway in dahl salt-sensitive rats.
PCSK9 Knockdown Can Improve Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy.
Title: PCSK9 Knockdown Can Improve Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy.
Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo.
Title: Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo.
PCSK9 inhibition protects against myocardial ischemia-reperfusion injury via suppressing autophagy.
Title: PCSK9 inhibition protects against myocardial ischemia-reperfusion injury via suppressing autophagy.
Protective Mechanism of Proprotein Convertase Subtilisin-Like Kexin Type 9 Inhibitor on Rats with Middle Cerebral Artery Occlusion-Induced Cerebral Ischemic Infarction.
Title: Protective Mechanism of Proprotein Convertase Subtilisin-Like Kexin Type 9 Inhibitor on Rats with Middle Cerebral Artery Occlusion-Induced Cerebral Ischemic Infarction.
Comparative Effect of Bergamot Polyphenolic Fraction and Red Yeast Rice Extract in Rats Fed a Hyperlipidemic Diet: Role of Antioxidant Properties and PCSK9 Expression.
Title: Comparative Effect of Bergamot Polyphenolic Fraction and Red Yeast Rice Extract in Rats Fed a Hyperlipidemic Diet: Role of Antioxidant Properties and PCSK9 Expression.
Autocrine effects of PCSK9 on cardiomyocytes.
Title: Autocrine effects of PCSK9 on cardiomyocytes.
Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.
Title: Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.
PCSK9: Associated with cardiac diseases and their risk factors?
Title: PCSK9: Associated with cardiac diseases and their risk factors?

Submit: New GeneRIF Correction See all GeneRIFs (36)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	ISS Inferred from Sequence or Structural Similarity more info
enables apolipoprotein receptor binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables signaling receptor inhibitor activity	ISO Inferred from Sequence Orthology more info
enables sodium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info
enables very-low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle receptor catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within low-density lipoprotein receptor particle metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor-mediated endocytosis involved in cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of low-density lipoprotein particle receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
part_of PCSK9-AnxA2 complex	ISO Inferred from Sequence Orthology more info
part_of PCSK9-LDLR complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proprotein convertase subtilisin/kexin type 9

Names: neural apoptosis-regulated convertase 1; proprotein convertase 9; proprotein convertase PC9; subtilisin/kexin-like protease PC9

NP_954862.2

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199253.2 → NP_954862.2 proprotein convertase subtilisin/kexin type 9 precursor

See identical proteins and their annotated locations for NP_954862.2

Status: PROVISIONAL

Source sequence(s)

AY847775

UniProtKB/Swiss-Prot

P59996, Q5I6U6

UniProtKB/TrEMBL

A6JYM6

Related

ENSRNOP00000008536.5, ENSRNOT00000008535.6

Conserved Domains (3) summary

cd04077
Location:155 → 420

Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins

pfam00082
Location:179 → 415

Peptidase_S8; Subtilase family

pfam05922
Location:76 → 148

Inhibitor_I9; Peptidase inhibitor I9