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    Kidins220 kinase D-interacting substrate 220 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116478, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kidins220provided by RGD
    Official Full Name
    kinase D-interacting substrate 220provided by RGD
    Primary source
    RGD:619949
    See related
    Ensembl:ENSRNOG00000023176 AllianceGenome:RGD:619949
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ARMS
    Summary
    Enables PDZ domain binding activity; protein kinase binding activity; and protein kinase regulator activity. Involved in nerve growth factor signaling pathway and positive regulation of neuron projection development. Located in late endosome. Part of protein-containing complex. Orthologous to human KIDINS220 (kinase D interacting substrate 220). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 458.8), Lung (RPKM 267.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q16
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (47346790..47435599)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (41618207..41706990)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (44225142..44322938)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479350 Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene ubiquinol-cytochrome-c reductase complex assembly factor 3-like Neighboring gene inhibitor of DNA binding 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes. López-Menéndez C, et al. Cell Death Dis, 2019 Jul 11. PMID 31296845, Free PMC Article
    2. Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa. Sutachan JJ, et al. J Neurosci Res, 2010 Dec. PMID 20936698
    3. Kidins220/ARMS downregulation by excitotoxic activation of NMDARs reveals its involvement in neuronal survival and death pathways. López-Menéndez C, et al. J Cell Sci, 2009 Oct 1. PMID 19759287
    4. The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity. Wu SH, et al. J Biol Chem, 2010 Dec 24. PMID 20943655, Free PMC Article
    5. Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo. Wu SH, et al. Dev Neurobiol, 2009 Aug. PMID 19449316, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Excitotoxicity induces Kidins220 and GluN1 traffic to the Golgi apparatus before Kidins220 is degraded by the protease calpain. Excitotoxicity also triggers an early activation of Rap1-GTPase followed by its inactivation. Kidins220 excitotoxic endocytosis and subsequent calpain-mediated downregulation governs inactivation of Rap1 that is associated to decreases in ERK activity preceding neuronal death.
      Title: Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes.
    2. This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease.
      Title: Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.
    3. overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF
      Title: ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated secretion.
    4. the existence of novel Kidins220/ARMS splice isoforms with unique properties
      Title: Novel Kidins220/ARMS Splice Isoforms: Potential Specific Regulators of Neuronal and Cardiovascular Development.
    5. a novel partner of Kidins220/ARMS
      Title: Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains.
    6. findings show that Kidins220/ARMS is a novel component of the uropod involved in the regulation of T-cell motility, an essential process for the immune response
      Title: The neuronal protein Kidins220/ARMS associates with ICAM-3 and other uropod components and regulates T-cell motility.
    7. A decrease in ARMS/Kidins220 levels suppressed GABAergic neurotransmission; overexpression of ARMS/Kidins220 produced an increase in GABAergic neurotransmission in hippocampal neurons; ARMS/Kidins220 regulates GABAergic neurotransmission presynaptically.
      Title: Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa.
    8. the levels of ARMS/Kidins220 can be regulated by neuronal activity and calpain action to influence synaptic function.
      Title: The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity.
    9. The direct interaction between ARMS/Kidins220 and Sept5 suggests a possible role of ARMS/Kidins220 as a functional link between neurotrophin receptors and septins to mediate neurotrophin-induced intracellular signaling events.
      Title: Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5.
    10. Kidins220 regulates Rac1-dependent neurite outgrowth by direct interaction with the Trio.
      Title: Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nerve growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinase D-interacting substrate of 220 kDa
    Names
    ankyrin repeat-rich membrane-spanning protein
    kinase D-interacting substance 220
    kinase D-interacting substance of 220 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053795.2 → NP_446247.2  kinase D-interacting substrate of 220 kDa

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000082934.1, ENSRNOT00000099104.1
      Conserved Domains (5) summary
      PHA02736
      Location:348 → 412
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 377
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:440 → 953
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      47346790..47435599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593983.3 → XP_017449472.1  kinase D-interacting substrate of 220 kDa isoform X18

      Related
      ENSRNOP00000085209.1

    2. XM_063261411.1 → XP_063117481.1  kinase D-interacting substrate of 220 kDa isoform X22

    3. XM_063261414.1 → XP_063117484.1  kinase D-interacting substrate of 220 kDa isoform X26

    4. XM_063261417.1 → XP_063117487.1  kinase D-interacting substrate of 220 kDa isoform X29

    5. XM_063261421.1 → XP_063117491.1  kinase D-interacting substrate of 220 kDa isoform X33

    6. XM_063261419.1 → XP_063117489.1  kinase D-interacting substrate of 220 kDa isoform X31

    7. XM_063261423.1 → XP_063117493.1  kinase D-interacting substrate of 220 kDa isoform X35

    8. XM_006239925.5 → XP_006239987.1  kinase D-interacting substrate of 220 kDa isoform X1

      UniProtKB/TrEMBL
      A6HAY7
      Conserved Domains (5) summary
      cd00204
      Location:32 → 191
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    9. XM_063261399.1 → XP_063117469.1  kinase D-interacting substrate of 220 kDa isoform X3

    10. XM_063261404.1 → XP_063117474.1  kinase D-interacting substrate of 220 kDa isoform X9

    11. XM_063261405.1 → XP_063117475.1  kinase D-interacting substrate of 220 kDa isoform X11

    12. XM_039111617.2 → XP_038967545.1  kinase D-interacting substrate of 220 kDa isoform X12

      UniProtKB/TrEMBL
      A0A8I6AHD1, A6HAY7
      Related
      ENSRNOP00000092341.1
      Conserved Domains (5) summary
      PHA02736
      Location:349 → 413
      PHA02736; Viral ankyrin protein; Provisional
      PHA02874
      Location:49 → 378
      PHA02874; ankyrin repeat protein; Provisional
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)

    13. XM_006239937.5 → XP_006239999.1  kinase D-interacting substrate of 220 kDa isoform X17

      UniProtKB/TrEMBL
      A6HAY8, D4ABK9
      Related
      ENSRNOP00000005858.7
      Conserved Domains (5) summary
      cd00204
      Location:32 → 191
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:441 → 954
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    14. XM_006239927.5 → XP_006239989.1  kinase D-interacting substrate of 220 kDa isoform X2

      Conserved Domains (5) summary
      cd00204
      Location:32 → 190
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:440 → 953
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    15. XM_006239928.5 → XP_006239990.1  kinase D-interacting substrate of 220 kDa isoform X4

      UniProtKB/TrEMBL
      A0A8I6AFW6
      Related
      ENSRNOP00000093485.1
      Conserved Domains (5) summary
      cd00204
      Location:32 → 190
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:440 → 953
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:42 → 133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:13 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    16. XM_017593979.3 → XP_017449468.1  kinase D-interacting substrate of 220 kDa isoform X10

      UniProtKB/TrEMBL
      D3ZWB2
      Related
      ENSRNOP00000063889.3

    17. XM_017593980.3 → XP_017449469.1  kinase D-interacting substrate of 220 kDa isoform X13

      Related
      ENSRNOP00000091847.1

    18. XM_063261408.1 → XP_063117478.1  kinase D-interacting substrate of 220 kDa isoform X16

    19. XM_039111622.2 → XP_038967550.2  kinase D-interacting substrate of 220 kDa isoform X19

    20. XM_039111623.2 → XP_038967551.2  kinase D-interacting substrate of 220 kDa isoform X23

    21. XM_063261409.1 → XP_063117479.1  kinase D-interacting substrate of 220 kDa isoform X20

    22. XM_063261412.1 → XP_063117482.1  kinase D-interacting substrate of 220 kDa isoform X24

    23. XM_063261410.1 → XP_063117480.1  kinase D-interacting substrate of 220 kDa isoform X21

    24. XM_063261413.1 → XP_063117483.1  kinase D-interacting substrate of 220 kDa isoform X25

    25. XM_063261416.1 → XP_063117486.1  kinase D-interacting substrate of 220 kDa isoform X28

    26. XM_063261415.1 → XP_063117485.1  kinase D-interacting substrate of 220 kDa isoform X27

    27. XM_063261420.1 → XP_063117490.1  kinase D-interacting substrate of 220 kDa isoform X32

    28. XM_063261418.1 → XP_063117488.1  kinase D-interacting substrate of 220 kDa isoform X30

    29. XM_063261422.1 → XP_063117492.1  kinase D-interacting substrate of 220 kDa isoform X34

    30. XM_063261400.1 → XP_063117470.1  kinase D-interacting substrate of 220 kDa isoform X5

    31. XM_063261401.1 → XP_063117471.1  kinase D-interacting substrate of 220 kDa isoform X6

    32. XM_063261402.1 → XP_063117472.1  kinase D-interacting substrate of 220 kDa isoform X7

    33. XM_063261403.1 → XP_063117473.1  kinase D-interacting substrate of 220 kDa isoform X8

    34. XM_063261406.1 → XP_063117476.1  kinase D-interacting substrate of 220 kDa isoform X14

    35. XM_063261407.1 → XP_063117477.1  kinase D-interacting substrate of 220 kDa isoform X15

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQG6.2 GenPept UniProtKB/Swiss-Prot:Q9EQG6

    Gene LinkOut

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