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    Gpr108 G protein-coupled receptor 108 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316136, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Gpr108provided by RGD
    Official Full Name
    G protein-coupled receptor 108provided by RGD
    Primary source
    RGD:735149
    See related
    Ensembl:ENSRNOG00000046128 AllianceGenome:RGD:735149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Predicted to be located in cis-Golgi network membrane and trans-Golgi network. Predicted to be active in Golgi apparatus and membrane. Orthologous to human GPR108 (G protein-coupled receptor 108). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 116.5), Lung (RPKM 107.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr108 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (2207716..2218738, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (2120740..2131771, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9704300..9714767)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene complement C3 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein GPR108

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199399.1 → NP_955431.1  protein GPR108 precursor

      See identical proteins and their annotated locations for NP_955431.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061996
      UniProtKB/Swiss-Prot
      M0R518, Q6P6V6
      Related
      ENSRNOP00000090899.1, ENSRNOT00000099188.1
      Conserved Domains (1) summary
      pfam06814
      Location:248 → 536
      Lung_7-TM_R; Lung seven transmembrane receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      2207716..2218738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244285.5 → XP_006244347.1  protein GPR108 isoform X1

      UniProtKB/Swiss-Prot
      M0R518, Q6P6V6
      Conserved Domains (1) summary
      pfam06814
      Location:248 → 547
      Lung_7-TM_R; Lung seven transmembrane receptor

    2. XM_039083463.2 → XP_038939391.1  protein GPR108 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AEE0, A0A8L2QWL5
      Related
      ENSRNOP00000064473.2
      Conserved Domains (1) summary
      pfam06814
      Location:230 → 517
      Lung_7-TM_R; Lung seven transmembrane receptor

    3. XM_006244286.4 → XP_006244348.1  protein GPR108 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEE0
      Conserved Domains (1) summary
      pfam06814
      Location:229 → 528
      Lung_7-TM_R; Lung seven transmembrane receptor

    4. XM_063267065.1 → XP_063123135.1  protein GPR108 isoform X5

      UniProtKB/TrEMBL
      A6KQR1

    5. XM_063267064.1 → XP_063123134.1  protein GPR108 isoform X5

      UniProtKB/TrEMBL
      A6KQR1

    6. XM_063267063.1 → XP_063123133.1  protein GPR108 isoform X4

      UniProtKB/TrEMBL
      A6KQR1

    7. XM_063267066.1 → XP_063123136.1  protein GPR108 isoform X6

      UniProtKB/TrEMBL
      A6KQR1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6V6.2 GenPept UniProtKB/Swiss-Prot:Q6P6V6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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