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    Slc33a1 solute carrier family 33 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64018, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc33a1provided by RGD
    Official Full Name
    solute carrier family 33 member 1provided by RGD
    Primary source
    RGD:620653
    See related
    Ensembl:ENSRNOG00000010023 AllianceGenome:RGD:620653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acatn
    Summary
    Predicted to enable solute:proton symporter activity. Predicted to be involved in BMP signaling pathway and SMAD protein signal transduction. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 42. Orthologous to human SLC33A1 (solute carrier family 33 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 245.5), Kidney (RPKM 221.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc33a1 in Genome Data Viewer
    Location:
    2q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (150565327..150587700, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (148415660..148438182, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (154520170..154542981, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, eta 1 Neighboring gene similar to human chromosome 3 open reading frame 33 Neighboring gene guanine monophosphate synthase Neighboring gene vomeronasal 2 receptor 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning of putative rat acetyl-CoA transporter and its expression pattern in brain. Bora RS, et al. Cytogenet Cell Genet, 2000. PMID 10965123
    2. Cloning and characterization of a putative mouse acetyl-CoA transporter cDNA. Bora RS, et al. Gene, 1999 Oct 1. PMID 10570973, Free PMC Article
    3. Identification and functional analysis of a SLC33A1: c.339T>G (p.Ser113Arg) variant in the original SPG42 family. Mao F, et al. Hum Mutat, 2015 Feb. PMID 25402622
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetyl-CoA transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyl-CoA transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acetyl-CoA transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acetyl-CoA transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-coenzyme A transporter 1
    Names
    AT-1
    acetyl-CoA transporter 1
    acetyl-coenzyme A transporter 1-like
    solute carrier family 33 (acetyl-CoA transporter), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022252.2 → NP_071588.2  acetyl-coenzyme A transporter 1

      See identical proteins and their annotated locations for NP_071588.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078832
      UniProtKB/Swiss-Prot
      Q6AYY8, Q9JM68
      UniProtKB/TrEMBL
      A6JVP5
      Related
      ENSRNOP00000013392.3, ENSRNOT00000013392.6
      Conserved Domains (1) summary
      TIGR00901
      Location:86 → 459
      2A0125; AmpG-like permease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      150565327..150587700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761058.2 → XP_008759280.1  acetyl-coenzyme A transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_008759280.1

      UniProtKB/Swiss-Prot
      Q6AYY8, Q9JM68
      UniProtKB/TrEMBL
      A6JVP5
      Conserved Domains (1) summary
      TIGR00901
      Location:86 → 459
      2A0125; AmpG-like permease

    2. XM_039103030.2 → XP_038958958.1  acetyl-coenzyme A transporter 1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:48 → 270
      MFS; Major Facilitator Superfamily

    3. XM_063282448.1 → XP_063138518.1  acetyl-coenzyme A transporter 1 isoform X2

    4. XM_039103029.2 → XP_038958957.1  acetyl-coenzyme A transporter 1 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:14 → 236
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYY8.1 GenPept UniProtKB/Swiss-Prot:Q6AYY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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