U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Psmb1 proteasome 20S subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94198, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Psmb1provided by RGD
    Official Full Name
    proteasome 20S subunit beta 1provided by RGD
    Primary source
    RGD:621092
    See related
    Ensembl:ENSRNOG00000001488 AllianceGenome:RGD:621092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in nucleus. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 881.9), Heart (RPKM 866.6) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Psmb1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (65115770..65136516, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (56442432..56463544, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (57470878..57491359, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120 member B Neighboring gene delta like canonical Notch ligand 1 Neighboring gene uncharacterized LOC102557016 Neighboring gene TATA box binding protein Neighboring gene programmed cell death 2 Neighboring gene BRCA1 associated RING domain 1, pseudogene 1 Neighboring gene PR/SET domain 9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. cDNA cloning and sequencing of component C5 of proteasomes from rat hepatoma cells. Tamura T, et al. FEBS Lett, 1990 May 7. PMID 2338147
    2. The NH2-terminal residues of rat liver proteasome (multicatalytic proteinase complex) subunits, C2, C3 and C8, are N alpha-acetylated. Tokunaga F, et al. FEBS Lett, 1990 Apr 24. PMID 2335242
    3. A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1. Moscovitz O, et al. Mol Cell, 2012 Jul 13. PMID 22793692
    4. Regulation of CD8+ T cell development by thymus-specific proteasomes. Murata S, et al. Science, 2007 Jun 1. PMID 17540904
    5. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    proteasome subunit beta type-1
    Names
    macropain subunit C5
    multicatalytic endopeptidase complex subunit C5
    proteasome (prosome, macropain) subunit, beta type 1
    proteasome beta 1 subunit
    proteasome component C5
    proteasome gamma chain
    proteasome subunit RC5
    proteasome subunit beta 1
    NP_446042.1
    XP_038949069.1
    XP_038949071.1
    XP_063132072.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053590.1 → NP_446042.1  proteasome subunit beta type-1 precursor

      See identical proteins and their annotated locations for NP_446042.1

      Status: PROVISIONAL

      Source sequence(s)
      X52783
      UniProtKB/Swiss-Prot
      P18421
      Conserved Domains (1) summary
      cd03757
      Location:29 → 240
      proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      65115770..65136516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093141.2 → XP_038949069.1  proteasome subunit beta type-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZZ8
      Related
      ENSRNOP00000085774.1
      Conserved Domains (1) summary
      cd03757
      Location:21 → 223
      proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    2. XM_063276002.1 → XP_063132072.1  proteasome subunit beta type-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y6U8, Q6PDW4

    3. XM_039093143.2 → XP_038949071.1  proteasome subunit beta type-1 isoform X3

      UniProtKB/TrEMBL
      A6KB45
      Conserved Domains (1) summary
      cl00467
      Location:1 → 140
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18421.3 GenPept UniProtKB/Swiss-Prot:P18421

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous