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    Aoc1 amine oxidase, copper-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 76507, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Aoc1provided by MGI
    Official Full Name
    amine oxidase, copper-containing 1provided by MGI
    Primary source
    MGI:MGI:1923757
    See related
    Ensembl:ENSMUSG00000029811 AllianceGenome:MGI:1923757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAO; Abp1; 1600012D06Rik
    Summary
    Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in several processes, including cellular response to azide; cellular response to copper ion starvation; and cellular response to histamine. Predicted to act upstream of or within amiloride transport. Predicted to be located in bicellular tight junction and extracellular exosome. Predicted to be active in plasma membrane. Is expressed in mesonephros and urinary system. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 196.7), small intestine adult (RPKM 189.0) and 2 other tissues See more
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    Genomic context

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    See Aoc1 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.78 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48872189..48886122)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48895255..48909188)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 176A Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932 Neighboring gene STARR-seq mESC enhancer starr_15799 Neighboring gene amine oxidase copper containing 1-like 2 Neighboring gene predicted gene, 24348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine. Karer M, et al. Inflamm Res, 2022 Apr. PMID 35303133, Free PMC Article
    2. Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Liang XH, et al. Endocrinology, 2010 Oct. PMID 20668027
    3. Amine oxidase copper-containing 1 (AOC1) is a downstream target gene of the Wilms tumor protein, WT1, during kidney development. Kirschner KM, et al. J Biol Chem, 2014 Aug 29. PMID 25037221, Free PMC Article
    4. The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1. Haag N, et al. J Neurosci, 2012 Dec 5. PMID 23223303, Free PMC Article
    5. Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts. Boateng LR, et al. J Cell Sci, 2012 Mar 1. PMID 22303001, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings suggest that WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis
      Title: Amine oxidase copper-containing 1 (AOC1) is a downstream target gene of the Wilms tumor protein, WT1, during kidney development.
    2. F-actin-anchored Cobl/Abp1 complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells in the cerebellar cortex.
      Title: The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.
    3. study identifies a role for the actin binding protein mAbp1 in the formation of podosome rosettes and regulation of invasive cell migration
      Title: Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts.
    4. Abp1 may be essential for mouse embryo implantation and decidualization.
      Title: Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histamine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylputrescine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary amine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables primary amine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables propane-1,3-diamine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables putrescine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to copper ion starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in putrescine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to antibiotic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amiloride-sensitive amine oxidase [copper-containing]
    Names
    ABP
    amiloride binding protein 1 (amine oxidase, copper-containing)
    amiloride-binding protein 1
    amiloride-sensitive amine oxidase
    amine oxidase copper domain-containing protein 1
    diamine oxidase
    histaminase
    NP_001155093.1
    NP_001155094.1
    NP_083914.2
    XP_030111522.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161621.1 → NP_001155093.1  amiloride-sensitive amine oxidase [copper-containing] precursor

      See identical proteins and their annotated locations for NP_001155093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC159547, AK146078
      Consensus CDS
      CCDS51767.1
      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Related
      ENSMUSP00000124085.2, ENSMUST00000162948.7
      Conserved Domains (3) summary
      pfam02727
      Location:44 → 129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146 → 245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305 → 717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain

    2. NM_001161622.1 → NP_001155094.1  amiloride-sensitive amine oxidase [copper-containing] precursor

      See identical proteins and their annotated locations for NP_001155094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.
      Source sequence(s)
      AC159547, AK146078, BB868807
      Consensus CDS
      CCDS51767.1
      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Related
      ENSMUSP00000128816.2, ENSMUST00000167529.3
      Conserved Domains (3) summary
      pfam02727
      Location:44 → 129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146 → 245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305 → 717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain

    3. NM_029638.2 → NP_083914.2  amiloride-sensitive amine oxidase [copper-containing] precursor

      See identical proteins and their annotated locations for NP_083914.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.
      Source sequence(s)
      AC159547, AK146078, BY131896
      Consensus CDS
      CCDS51767.1
      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Related
      ENSMUSP00000031835.8, ENSMUST00000031835.14
      Conserved Domains (3) summary
      pfam02727
      Location:44 → 129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146 → 245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305 → 717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48872189..48886122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255662.1 → XP_030111522.1  amiloride-sensitive amine oxidase [copper-containing] isoform X1

      UniProtKB/TrEMBL
      E9PYN9, Q3UKB9
      Conserved Domains (3) summary
      pfam02727
      Location:44 → 129
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:146 → 245
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain
      pfam01179
      Location:305 → 717
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZQ5.1 GenPept UniProtKB/Swiss-Prot:Q8JZQ5

    Gene LinkOut

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