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    Rhbdl2 rhomboid like 2 [ Mus musculus (house mouse) ]

    Gene ID: 230726, updated on 8-May-2024

    Summary

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    Official Symbol
    Rhbdl2provided by MGI
    Official Full Name
    rhomboid like 2provided by MGI
    Primary source
    MGI:MGI:3608413
    See related
    Ensembl:ENSMUSG00000043333 AllianceGenome:MGI:3608413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RRP2; 9130416B15
    Summary
    Enables serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in plasma membrane. Is expressed in bone; genitourinary system; and rib. Orthologous to human RHBDL2 (rhomboid like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 4.9), colon adult (RPKM 4.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rhbdl2 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123681642..123723993)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123787875..123830196)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6212 Neighboring gene predicted gene, 57730 Neighboring gene akirin 1 Neighboring gene STARR-positive B cell enhancer ABC_E1654 Neighboring gene STARR-seq mESC enhancer starr_11313 Neighboring gene STARR-seq mESC enhancer starr_11314 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene Neighboring gene RIKEN cDNA 1700121C08 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing. Cheng TL, et al. J Invest Dermatol, 2011 Dec. PMID 21833011
    2. Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Zettl M, et al. Cell, 2011 Apr 1. PMID 21439629, Free PMC Article
    3. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rhomboid-related protein 2
    Names
    rhomboid, veinlet-like 2
    NP_001343374.1
    NP_898986.2
    XP_006503088.1
    XP_036019936.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356445.2 → NP_001343374.1  rhomboid-related protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683811
      Conserved Domains (1) summary
      pfam01694
      Location:51 → 203
      Rhomboid; Rhomboid family

    2. NM_183163.3 → NP_898986.2  rhomboid-related protein 2 isoform 1

      See identical proteins and their annotated locations for NP_898986.2

      Status: VALIDATED

      Source sequence(s)
      AL683811
      Consensus CDS
      CCDS38873.1
      UniProtKB/Swiss-Prot
      A2AGA4
      Related
      ENSMUSP00000054546.6, ENSMUST00000053202.12
      Conserved Domains (1) summary
      pfam01694
      Location:115 → 264
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      123681642..123723993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503025.5 → XP_006503088.1  rhomboid-related protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006503088.1

      UniProtKB/Swiss-Prot
      A2AGA4
      Related
      ENSMUSP00000101810.2, ENSMUST00000106204.2
      Conserved Domains (1) summary
      pfam01694
      Location:115 → 264
      Rhomboid; Rhomboid family

    2. XM_036164043.1 → XP_036019936.1  rhomboid-related protein 2 isoform X2

      Conserved Domains (1) summary
      pfam01694
      Location:51 → 203
      Rhomboid; Rhomboid family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AGA4.1 GenPept UniProtKB/Swiss-Prot:A2AGA4

    Gene LinkOut

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