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    Enpp4 ectonucleotide pyrophosphatase/phosphodiesterase 4 [ Mus musculus (house mouse) ]

    Gene ID: 224794, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Enpp4provided by MGI
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 4provided by MGI
    Primary source
    MGI:MGI:2682634
    See related
    Ensembl:ENSMUSG00000023961 AllianceGenome:MGI:2682634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm90; E-NPP 4; 4933413N07Rik
    Summary
    Predicted to enable bis(5'-adenosyl)-triphosphatase activity. Predicted to be involved in positive regulation of blood coagulation and purine ribonucleoside catabolic process. Predicted to act upstream of or within blood coagulation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in bladder; limb; limb musculature; pancreas epithelium; and thymus primordium. Orthologous to human ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.4), genital fat pad adult (RPKM 5.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B3; 17 20.34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (44407198..44416725, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (44096307..44105809, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34857 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 5 Neighboring gene predicted gene, 34917 Neighboring gene chloride intracellular channel 5 Neighboring gene STARR-seq mESC enhancer starr_42608 Neighboring gene STARR-positive B cell enhancer ABC_E5611 Neighboring gene STARR-seq mESC enhancer starr_42609 Neighboring gene STARR-seq mESC enhancer starr_42610 Neighboring gene STARR-seq mESC enhancer starr_42611 Neighboring gene runt related transcription factor 2 Neighboring gene runt related transcription factor 2, opposite strand 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Homology modeling and docking studies of ENPP4: a BCG activated tumoricidal macrophage protein. Yan D, et al. Lipids Health Dis, 2016 Jan 28. PMID 26823374, Free PMC Article
    2. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, et al. J Med Genet, 2002 Sep. PMID 12205107, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29265

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-triphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine ribonucleoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bis(5'-adenosyl)-triphosphatase enpp4
    Names
    AP3A hydrolase
    AP3Aase
    E-NPP4
    NPP-4
    ectonucleotide pyrophosphatase/phosphodiesterase family member 4
    NP_001344925.1
    NP_001344926.1
    NP_950181.2
    XP_006524196.1
    XP_017172927.1
    XP_036016444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357996.1 → NP_001344925.1  bis(5'-adenosyl)-triphosphatase enpp4 precursor

      Status: VALIDATED

      Source sequence(s)
      AI854294, CT030230
      Consensus CDS
      CCDS28803.1
      UniProtKB/Swiss-Prot
      Q3TZS2, Q69ZX0, Q8BTJ4, Q8K1L3
      Related
      ENSMUSP00000114429.2, ENSMUST00000143137.2
      Conserved Domains (1) summary
      cd16018
      Location:29 → 382
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. NM_001357997.1 → NP_001344926.1  bis(5'-adenosyl)-triphosphatase enpp4 precursor

      Status: VALIDATED

      Source sequence(s)
      AI854294, CT030230
      Consensus CDS
      CCDS28803.1
      UniProtKB/Swiss-Prot
      Q3TZS2, Q69ZX0, Q8BTJ4, Q8K1L3
      Conserved Domains (1) summary
      cd16018
      Location:29 → 382
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    3. NM_199016.2 → NP_950181.2  bis(5'-adenosyl)-triphosphatase enpp4 precursor

      See identical proteins and their annotated locations for NP_950181.2

      Status: VALIDATED

      Source sequence(s)
      CAAA01049488, CB723093, CJ182752, CO044941
      Consensus CDS
      CCDS28803.1
      UniProtKB/Swiss-Prot
      Q3TZS2, Q69ZX0, Q8BTJ4, Q8K1L3
      Related
      ENSMUSP00000024757.8, ENSMUST00000024757.14
      Conserved Domains (1) summary
      cd16018
      Location:29 → 382
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      44407198..44416725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160551.1 → XP_036016444.1  bis(5'-adenosyl)-triphosphatase enpp4 isoform X3

      Conserved Domains (1) summary
      cd16018
      Location:29 → 381
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. XM_017317438.1 → XP_017172927.1  bis(5'-adenosyl)-triphosphatase enpp4 isoform X2

      Conserved Domains (1) summary
      cd16018
      Location:43 → 395
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    3. XM_006524133.1 → XP_006524196.1  bis(5'-adenosyl)-triphosphatase enpp4 isoform X1

      Conserved Domains (1) summary
      cd16018
      Location:43 → 396
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTJ4.1 GenPept UniProtKB/Swiss-Prot:Q8BTJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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